Astrocyte senescence as a component of Alzheimer's disease (Q34416365)

2 August 2017

title

Astrocyte senescence as a component of Alzheimer's disease (English)

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2 August 2017

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8

John Q Trojanowski

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2 August 2017

5

Christos D Katsetos

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2 August 2017

Rekha Bhat

1

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2 August 2017

Elizabeth P Crowe

2

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2 August 2017

Alessandro Bitto

3

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2 August 2017

Michelle Moh

4

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2 August 2017

Fernando U Garcia

6

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2 August 2017

Frederick Bradley Johnson

7

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2 August 2017

Christian Sell

9

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2 August 2017

Claudio Torres

10

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2 August 2017

language of work or name

English

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publication date

12 September 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

9

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2 August 2017

page(s)

e45069

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

12 September 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

2012 Alzheimer's disease facts and figures

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

6 July 2018

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Cellular senescence: a link between cancer and age-related degenerative disease?

6 July 2018

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Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype

6 July 2018

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Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

6 July 2018

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Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

6 July 2018

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Ethnoracial differences in the clinical characteristics of Alzheimer's disease at initial presentation at an urban Alzheimer's disease center

6 July 2018

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p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

6 July 2018

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Four faces of cellular senescence.

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Reactive astrocytes as therapeutic targets for CNS disorders

6 July 2018

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Preparation of oligomeric beta-amyloid 1-42 and induction of synaptic plasticity impairment on hippocampal slices

6 July 2018

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Inflammatory networks during cellular senescence: causes and consequences

6 July 2018

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Senescent cells as a source of inflammatory factors for tumor progression

6 July 2018

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6 July 2018

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Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability

6 July 2018

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Aβ oligomers inhibit synapse remodelling necessary for memory consolidation

6 July 2018

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The senescence-associated secretory phenotype: the dark side of tumor suppression

6 July 2018

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Astrocytes: biology and pathology

6 July 2018

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Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

6 July 2018

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Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases

6 July 2018

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Tripartite synapses: roles for astrocytic purines in the control of synaptic physiology and behavior

6 July 2018

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Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

6 July 2018

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Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells

6 July 2018

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Oligomers of the amyloid-beta protein disrupt working memory: confirmation with two behavioral procedures.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Cellular senescence and organismal aging

6 July 2018

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Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

6 July 2018

1 reference

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Accumulation of senescent cells in mitotic tissue of aging primates

6 July 2018

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Interleukin-6 in aging and chronic disease: a magnificent pathway

6 July 2018

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

6 July 2018

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Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

6 July 2018

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Ink4a/Arf expression is a biomarker of aging

6 July 2018

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Genetics of somatic mammalian cells. III. Long-term cultivation of euploid cells from human and animal subjects

6 July 2018

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Alzheimer Disease in the US Population

6 July 2018

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Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway

6 July 2018

1 reference

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In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Amyloid-beta peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

The effects of amyloid-β42 oligomer on the proliferation and activation of astrocytes in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

2011 Alzheimer's disease facts and figures

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Stress-induced senescence in human and rodent astrocytes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Abeta peptides accelerate the senescence of endothelial cells in vitro and in vivo, impairing angiogenesis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Astrocytes aged in vitro show a decreased neuroprotective capacity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Cellular senescence in aging primates.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Cerebellar diffuse amyloid plaques are derived from dendritic Abeta42 accumulations in Purkinje cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3440417

Age trends in autopsy rates. Striking decline in late life

27 October 2018

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12 December 2020

Differential regulation of collagenase and stromelysin mRNA in late passage cultures of human fibroblasts

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12 December 2020

Alveolar cell senescence in patients with pulmonary emphysema

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12 December 2020

Increased expression of p16(INK4a) and p27(Kip1) cyclin-dependent kinase inhibitor genes in aging human kidney and chronic allograft nephropathy

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12 December 2020

Inflammatory processes in Alzheimer's disease

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12 December 2020

Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure

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12 December 2020

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0045069

Identifiers

DOI

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2 August 2017

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2 August 2017

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