Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity (Q34416920)

2 August 2017

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity (English)

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2 August 2017

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3

Arne Holmgren

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2 August 2017

Jianguo Fang

1

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PubMed ID

15879598

2 August 2017

Jun Lu

series ordinal

2

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PubMed ID

15879598

2 August 2017

language of work or name

English

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publication date

6 May 2005

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Journal of Biological Chemistry

2 August 2017

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2 August 2017

280

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2 August 2017

25284-25290

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2 August 2017

26

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Biological properties of curcumin-cellular and molecular mechanisms of action

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Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

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Inhibition of human low density lipoprotein oxidation by active principles from spices

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Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication

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Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells.

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Recent studies on the biofunctions and biotransformations of curcumin

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Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction

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The thioredoxin system—From science to clinic

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Physiological functions of thioredoxin and thioredoxin reductase

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

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Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

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Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations

21 January 2018

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Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

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Thioredoxin reductase as a pathophysiological factor and drug target

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High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes

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Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha.

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Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.

21 January 2018

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Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

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A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity

21 January 2018

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Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

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Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

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Antioxidant function of thioredoxin and glutaredoxin systems

21 January 2018

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NK-lysin, a disulfide-containing effector peptide of T-lymphocytes, is reduced and inactivated by human thioredoxin reductase. Implication for a protective mechanism against NK-lysin cytotoxicity.

21 January 2018

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.

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NF-kappaB in cancer: from innocent bystander to major culprit

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Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

21 January 2018

1 reference

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Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

21 January 2018

1 reference

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21 January 2018

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Inactivation of protein disulfide isomerase by alkylators including alpha,beta-unsaturated aldehydes at low physiological pHs.

21 January 2018

1 reference

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Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.

21 January 2018

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Curcumin impairs tumor suppressor p53 function in colon cancer cells

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Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

21 January 2018

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Gene expression and the thiol redox state

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Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase

21 January 2018

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Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase

21 January 2018

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The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

21 January 2018

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Curcumin-induced histone hypoacetylation: the role of reactive oxygen species

21 January 2018

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Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.

21 January 2018

1 reference

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Pharmacology of Curcuma longa

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Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.

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The emerging role of reactive oxygen species in cancer therapy

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ROS stress in cancer cells and therapeutic implications

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Identifiers

DOI

10.1074/JBC.M414645200

1 reference

2 August 2017

1 reference

PubMed ID

15879598