Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study. (Q34418695)

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English	Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.	scientific article

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17 March 2020

Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study (English)

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17 March 2020

Friedreich ataxia

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6

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17 March 2020

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Vincenzo Libri

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17 March 2020

Cihangir Yandim

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Stavros Athanasopoulos

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Naomi Loyse

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Theona Natisvili

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Ping Kei Chan

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Tariq Mohammad

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Kin Tung Tam

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Sophie Piper

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Michael H Parkinson

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Les Huson

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17 March 2020

Richard Festenstein

17

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17 March 2020

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30 April 2014

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17 March 2020

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17 March 2020

384

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17 March 2020

9942

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17 March 2020

504-513

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17 March 2020

Friedreich's ataxia: pathology, pathogenesis, and molecular genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Nikolaus Friedreich and degenerative atrophy of the dorsal columns of the spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical and genetic abnormalities in patients with Friedreich's ataxia

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https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

inferred from DOI database lookup

Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

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Gene regulation and epigenetics in Friedreich's ataxia

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https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

based on heuristic

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A review of Friedreich ataxia clinical trial results

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7 January 2021

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Erythropoietin in Friedreich ataxia: No effect on frataxin in a randomized controlled trial

1 reference

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7 January 2021

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DNA triplet repeats mediate heterochromatin-protein-1-sensitive variegated gene silencing

1 reference

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7 January 2021

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Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.

1 reference

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7 January 2021

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Epigenetic silencing in Friedreich ataxia is associated with depletion of CTCF (CCCTC-binding factor) and antisense transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

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Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.

1 reference

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7 January 2021

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Regulation of chromatin by histone modifications

1 reference

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7 January 2021

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Translating the Histone Code

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

1 reference

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7 January 2021

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Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability

1 reference

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7 January 2021

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SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

1 reference

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Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor

1 reference

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Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model

1 reference

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7 January 2021

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HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model

1 reference

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7 January 2021

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Breaking the silence in Friedreich's ataxia

1 reference

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7 January 2021

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Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

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7 January 2021

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Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction

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SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

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7 January 2021

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The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury.

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

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inferred from DOI database lookup

Safety of high-dose nicotinamide: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0140-6736%2814%2960382-2

7 January 2021

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inferred from DOI database lookup

Niacin and niacinamide accumulation by rabbit brain slices and choroid plexus in vitro

1 reference

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7 January 2021

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Pharmacokinetics and biochemistry studies on nicotinamide in the mouse

1 reference

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7 January 2021

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European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes

1 reference

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7 January 2021

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A combined nucleic acid and protein analysis in Friedreich ataxia: implications for diagnosis, pathogenesis and clinical trial design

1 reference

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7 January 2021

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inferred from DOI database lookup

Lateral-flow immunoassay for the frataxin protein in Friedreich's ataxia patients and carriers

1 reference

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7 January 2021

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Scale for the assessment and rating of ataxia: development of a new clinical scale

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7 January 2021

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SCA Functional Index: a useful compound performance measure for spinocerebellar ataxia.

1 reference

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7 January 2021

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inferred from DOI database lookup

Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale.

1 reference

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7 January 2021

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inferred from DOI database lookup

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7 January 2021

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1 reference

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7 January 2021

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Preventing the ubiquitin–proteasome-dependent degradation of frataxin, the protein defective in Friedreich's ataxia

1 reference

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7 January 2021

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inferred from DOI database lookup

Coenzyme Q10 and nicotinamide block striatal lesions produced by the mitochondrial toxin malonate

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10.1016/S0140-6736(14)60382-2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24794816%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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