The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. (Q34419977)

2 August 2017

title

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. (English)

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2 August 2017

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29

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Eileen Hu

11

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Xudong Fu

Xudong Fu

2

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Gregory M Solis

Gregory M Solis

15

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Farbod Fazlollahi

Farbod Fazlollahi

16

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Stephen A Whelan

Stephen A Whelan

12

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Michael Petrascheck

Michael Petrascheck

32

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Laurent Vergnes

Laurent Vergnes

4

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Karen Reue

33

Karen Reue

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2 August 2017

30

Catherine F Clarke

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author name string

Randall M Chin

1

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2 August 2017

Melody Y Pai

3

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2 August 2017

Heejun Hwang

5

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2 August 2017

Gang Deng

6

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2 August 2017

Simon Diep

7

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2 August 2017

Brett Lomenick

8

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2 August 2017

Vijaykumar S Meli

9

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2 August 2017

Gabriela C Monsalve

10

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2 August 2017

Jennifer X Wang

13

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Gwanghyun Jung

14

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2 August 2017

Chitrada Kaweeteerawat

17

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2 August 2017

Austin Quach

18

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2 August 2017

Mahta Nili

19

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Abby S Krall

20

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2 August 2017

Hilary A Godwin

21

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2 August 2017

Helena R Chang

22

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2 August 2017

Kym F Faull

23

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2 August 2017

Feng Guo

24

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2 August 2017

Meisheng Jiang

25

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2 August 2017

Sunia A Trauger

26

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2 August 2017

Alan Saghatelian

27

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Daniel Braas

28

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Michael A Teitell

31

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Michael E Jung

34

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Alison R Frand

35

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Jing Huang

36

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2 August 2017

language of work or name

English

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publication date

14 May 2014

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2 August 2017

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2 August 2017

volume

510

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2 August 2017

issue

7505

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2 August 2017

page(s)

397-401

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describes a project that uses

2 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4263271/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Synthesis of the 1-monoester of 2-ketoalkanedioic acids, for example, octyl α-ketoglutarate

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Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway

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Caloric restriction delays disease onset and mortality in rhesus monkeys

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

6 July 2018

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The TOR pathway comes of age

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

6 July 2018

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Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.

6 July 2018

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Hierarchical phosphorylation of the translation inhibitor 4E-BP1

6 July 2018

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

6 July 2018

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Mitochondrial respiratory chain deficiency in Caenorhabditis elegans results in developmental arrest and increased life span

6 July 2018

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

6 July 2018

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Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans.

6 July 2018

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Specific interference by ingested dsRNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263271

The genetics of caloric restriction in Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263271

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

6 July 2018

1 reference

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The modular phosphorylation and activation of p70s6k.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263271

The ATP synthase--a splendid molecular machine

6 July 2018

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Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria

6 July 2018

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Metabolites of citric acid cycle, carbohydrate and phosphorus metabolism, and related reactions, redox and phosphorylating states of hepatic tissue, liver mitochondria and cytosol of the pigeon, under normal feeding and natural nocturnal fasting con

6 July 2018

1 reference

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The genetics of Caenorhabditis elegans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263271

Target identification using drug affinity responsive target stability (DARTS)

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13264

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNATURE13264

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13264

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13264

C. elegans behavior of preference choice on bacterial food.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13264

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13264

The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE13264

Measuring Caenorhabditis elegans life span on solid media

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4263271

27 October 2018

Identifiers

DOI

10.1038/NATURE13264

1 reference

2 August 2017

1 reference

2 August 2017

1 reference