TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation (Q44133461)

30 November 2017

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation (English)

1 reference

Target of rapamycin homolog CELE_B0261.2

30 November 2017

Caenorhabditis elegans

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1 reference

GOA release 2020-03-11

author name string

Xiaomeng Long

1

1 reference

30 November 2017

Carmen Spycher

2

1 reference

30 November 2017

Z Stanley Han

3

1 reference

30 November 2017

Ann M Rose

4

1 reference

30 November 2017

Fritz Müller

5

1 reference

30 November 2017

Joseph Avruch

6

1 reference

30 November 2017

language of work or name

English

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publication date

1 September 2002

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30 November 2017

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30 November 2017

12

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30 November 2017

1448-1461

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30 November 2017

17

1 reference

Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

30 November 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

TOR controls translation initiation and early G1 progression in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Target of rapamycin proteins and their kinase activities are required for meiosis

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

A protein conjugation system essential for autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Tor-mediated induction of autophagy via an Apg1 protein kinase complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Alpha 4 associates with protein phosphatases 2A, 4, and 6

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The Arabidopsis homolog of yeast TAP42 and mammalian alpha4 binds to the catalytic subunit of protein phosphatase 2A and is induced by chilling.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The TOR signal transduction cascade controls cellular differentiation in response to nutrients

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Arresting development arrests aging in the nematode Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

FAT: a novel domain in PIK-related kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The autofluorescent "lipofuscin granules" in the intestinal cells of Caenorhabditis elegans are secondary lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Distribution and transport of cholesterol in Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Drosophila S6 kinase: a regulator of cell size

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Multiple isoforms of eukaryotic protein synthesis initiation factor 4E in Caenorhabditis elegans can distinguish between mono- and trimethylated mRNA cap structures

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Functional characterization of five eIF4E isoforms in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Genetic control of cell size

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0960-9822%2802%2901091-6

7 January 2021

10.1016/S0960-9822(02)01091-6

Identifiers

DOI

1 reference

30 November 2017

1 reference