Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. (Q34427458)

2 August 2017

Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2. (English)

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2 August 2017

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Antonina Roll-Mecak

3

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Stephen K Burley

object named as

Stephen K Burley

5

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author name string

Anil K Padyana

1

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2 August 2017

Hongfang Qiu

2

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2 August 2017

Alan G Hinnebusch

4

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2 August 2017

language of work or name

English

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publication date

17 June 2005

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Journal of Biological Chemistry

2 August 2017

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2 August 2017

280

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2 August 2017

32

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2 August 2017

29289-29299

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Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

2 August 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Activation of GCN2 in UV-irradiated cells inhibits translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Dimerization by translation initiation factor 2 kinase GCN2 is mediated by interactions in the C-terminal ribosome-binding region and the protein kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Mutations that bypass tRNA binding activate the intrinsically defective kinase domain in GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Preparation of selenomethionyl proteins for phase determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

The CCP4 suite: programs for protein crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

A new software routine that automates the fitting of protein X-ray crystallographic electron-density maps.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Multiple sequence alignment with Clustal X

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Amino acid substitution matrices from protein blocks

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Large-scale protein structure modeling of the Saccharomyces cerevisiae genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Protein structure alignment by incremental combinatorial extension (CE) of the optimal path

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Crystal structure of cyclin-dependent kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Autophosphorylation in the activation loop is required for full kinase activity in vivo of human and yeast eukaryotic initiation factor 2alpha kinases PKR and GCN2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

The atomic structure of protein-protein recognition sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

The conformational plasticity of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Conformation of Polypeptides and Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

A strategy for the design of multiplex inhibitors for kinase-mediated signalling in angiogenesis

21 January 2018

1 reference

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Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

21 January 2018

1 reference

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Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504096200

21 January 2018

Identifiers

DOI

10.1074/JBC.M504096200

1 reference

2 August 2017

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