Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models (Q34427548)

2 August 2017

title

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models (English)

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2 August 2017

author

Michel C. Nussenzweig

15

object named as

Michel Nussenzweig

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2 August 2017

8

Galina V Petukhova

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2 August 2017

author name string

Simone Difilippantonio

1

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2 August 2017

Arkady Celeste

2

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2 August 2017

Oscar Fernandez-Capetillo

3

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2 August 2017

Hua-Tang Chen

4

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2 August 2017

Bernardo Reina San Martin

5

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2 August 2017

Francois Van Laethem

6

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2 August 2017

Yong-Ping Yang

7

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2 August 2017

Michael Eckhaus

9

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2 August 2017

Lionel Feigenbaum

10

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2 August 2017

Katia Manova

11

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2 August 2017

Michael Kruhlak

12

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2 August 2017

R Daniel Camerini-Otero

13

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2 August 2017

Shyam Sharan

14

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2 August 2017

André Nussenzweig

16

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2 August 2017

language of work or name

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19 June 2005

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

7

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2 August 2017

page(s)

675-685

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

2 August 2017

cites work

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The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together

21 January 2018

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Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

21 January 2018

1 reference

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

21 January 2018

1 reference

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

21 January 2018

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

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Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

21 January 2018

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A murine model of Nijmegen breakage syndrome

21 January 2018

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Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex

21 January 2018

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

21 January 2018

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Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

21 January 2018

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The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

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Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 January 2018

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Mre11 assembles linear DNA fragments into DNA damage signaling complexes

21 January 2018

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Chk2 activation dependence on Nbs1 after DNA damage

21 January 2018

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ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

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The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways

21 January 2018

1 reference

Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.

21 January 2018

1 reference

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

1 reference

A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragments

21 January 2018

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The cellular response to general and programmed DNA double strand breaks

21 January 2018

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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

21 January 2018

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ATM is required for efficient recombination between immunoglobulin switch regions

21 January 2018

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Immunoglobulin class switch recombination is impaired in Atm-deficient mice

21 January 2018

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Heterogeneity of humoral immune abnormalities in children with Nijmegen breakage syndrome: an 8-year follow-up study in a single centre.

21 January 2018

1 reference

Nibrin functions in Ig class-switch recombination

21 January 2018

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Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification

21 January 2018

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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

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Nbs1 is required for ATR-dependent phosphorylation events

21 January 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

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Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis

21 January 2018

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Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation

21 January 2018

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Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

21 January 2018

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The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity

21 January 2018

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An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability.

21 January 2018

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ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation

21 January 2018

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Genomic instability in mice lacking histone H2AX

21 January 2018

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Alternative end joining during switch recombination in patients with ataxia-telangiectasia

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCB1270

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Dimensions Publication ID

2 August 2017

1025699748

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