Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation (Q34428960)

2 August 2017

title

Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation (English)

1 reference

2 August 2017

1 reference

Alexander Lazar

6

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Vicki Huff

10

object named as

Vicki Huff

1 reference

2 August 2017

E. Cristy Ruteshouser

4

object named as

E Cristy Ruteshouser

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2 August 2017

1

Qianghua Hu

1 reference

2 August 2017

Fei Gao

2

1 reference

2 August 2017

Weihua Tian

3

1 reference

2 August 2017

Yaqing Wang

5

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2 August 2017

John Stewart

7

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2 August 2017

Louise C Strong

8

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2 August 2017

Richard R Behringer

9

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2 August 2017

language of work or name

English

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publication date

1 December 2010

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Journal of Clinical Investigation

2 August 2017

published in

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2 August 2017

volume

121

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2 August 2017

issue

1

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2 August 2017

page(s)

174-183

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Insulin and insulin-like growth factor signalling in neoplasia

2 August 2017

cites work

1 reference

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Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development

6 July 2018

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Wilms tumor genetics: mutations in WT1, WTX, and CTNNB1 account for only about one-third of tumors

6 July 2018

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6 July 2018

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Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

6 July 2018

1 reference

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An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

6 July 2018

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Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle

6 July 2018

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Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

6 July 2018

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Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney

6 July 2018

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The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis

6 July 2018

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Regulation of apoptosis by insulin-like growth factor (IGF)-I.

6 July 2018

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Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development

6 July 2018

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Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

6 July 2018

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Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

6 July 2018

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Six1 is required for the early organogenesis of mammalian kidney

6 July 2018

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Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney

6 July 2018

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Wnt-4 regulation by the Wilms' tumour suppressor gene, WT1.

6 July 2018

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Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition

6 July 2018

1 reference

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Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

6 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

6 July 2018

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Erk MAP kinase regulates branching morphogenesis in the developing mouse kidney

6 July 2018

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Frequent association of beta-catenin and WT1 mutations in Wilms tumors.

6 July 2018

1 reference

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The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin

6 July 2018

1 reference

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Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

The Wilms tumor suppressor gene wt1 is required for development of the spleen.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Cluster analysis and display of genome-wide expression patterns

6 July 2018

1 reference

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6 July 2018

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Differential expression and function of cadherin-6 during renal epithelium development

6 July 2018

1 reference

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Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2

6 July 2018

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Pax-2 controls multiple steps of urogenital development

6 July 2018

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WT-1 is required for early kidney development

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

6 July 2018

1 reference

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A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

6 July 2018

1 reference

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A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye

6 July 2018

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Disruption of imprinting caused by deletion of the H19 gene region in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Mutation and cancer: a model for Wilms' tumor of the kidney

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3007149

Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma

27 October 2018

1 reference

12 December 2020

Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour

1 reference

12 December 2020

Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour

1 reference

12 December 2020

Anaplastic Wilms' tumour, a subtype displaying poor prognosis, harbours p53 gene mutations

1 reference

12 December 2020

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

1 reference

12 December 2020

Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor

1 reference

12 December 2020

Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer

1 reference

12 December 2020

Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI43772

1 reference

2 August 2017

1 reference

2 August 2017

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