Enzyme promiscuity: engine of evolutionary innovation. (Q34430867)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25210039%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

review article

1 reference

title

Enzyme promiscuity: engine of evolutionary innovation (English)

1 reference

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16 February 2020

1 reference

1

1 reference

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16 February 2020

Karen N. Allen

series ordinal

4

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16 February 2020

author name string

Jeremiah D Farelli

series ordinal

2

1 reference

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16 February 2020

Debra Dunaway-Mariano

series ordinal

3

1 reference

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16 February 2020

language of work or name

English

0 references

publication date

10 September 2014

1 reference

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Journal of Biological Chemistry

16 February 2020

published in

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16 February 2020

volume

289

1 reference

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16 February 2020

issue

44

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16 February 2020

page(s)

30229-30236

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Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB

16 February 2020

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Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP

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Functional screening and in vitro analysis reveal thioesterases with enhanced substrate specificity profiles that improve short-chain fatty acid production in Escherichia coli

6 July 2018

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Differential active site loop conformations mediate promiscuous activities in the lactonase SsoPox

6 July 2018

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Structural Basis for the Divergence of Substrate Specificity and Biological Function within HAD Phosphatases in Lipopolysaccharide and Sialic Acid Biosynthesis

6 July 2018

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Evolution of a designed retro-aldolase leads to complete active site remodeling

6 July 2018

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What makes a protein fold amenable to functional innovation? Fold polarity and stability trade-offs

6 July 2018

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Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity

6 July 2018

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Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage

6 July 2018

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Network context and selection in the evolution to enzyme specificity.

6 July 2018

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Correlation of structure and function in the human hotdog-fold enzyme hTHEM4

6 July 2018

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Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801

6 July 2018

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Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1

6 July 2018

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Sampling the conformational energy landscape of a hyperthermophilic protein by engineering key substitutions

6 July 2018

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Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme

6 July 2018

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The X-ray crystallographic structure and specificity profile of HAD superfamily phosphohydrolase BT1666: Comparison of paralogous functions inB. thetaiotaomicron

6 July 2018

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Divergence of Structure and Function in the Haloacid Dehalogenase Enzyme Superfamily: Bacteroides thetaiotaomicron BT2127 Is an Inorganic Pyrophosphatase

6 July 2018

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Structural basis for the allosteric regulation and substrate recognition of human cytosolic 5'-nucleotidase II

6 July 2018

1 reference

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Probing enzyme promiscuity of SGNH hydrolases

6 July 2018

1 reference

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Structural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine Selectivity

6 July 2018

1 reference

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Enzyme promiscuity: a mechanistic and evolutionary perspective

6 July 2018

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An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily

6 July 2018

1 reference

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What makes an enzyme promiscuous?

6 July 2018

1 reference

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Protein dynamism and evolvability.

6 July 2018

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Protein promiscuity and its implications for biotechnology

6 July 2018

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The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis

6 July 2018

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Analysis of the Structural Determinants Underlying Discrimination between Substrate and Solvent in β-Phosphoglucomutase Catalysis † ‡

6 July 2018

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In vitro kinetic analysis of substrate specificity in enterobactin biosynthetic lower pathway enzymes provides insight into the biochemical function of the hot dog-fold thioesterase EntH

6 July 2018

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Structure of YciA from Haemophilus influenzae (HI0827), a hexameric broad specificity acyl-coenzyme A thioesterase

6 July 2018

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Evolutionary genomics of the HAD superfamily: understanding the structural adaptations and catalytic diversity in a superfamily of phosphoesterases and allied enzymes

6 July 2018

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The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.

6 July 2018

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Protein stability promotes evolvability

6 July 2018

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HAD superfamily phosphotransferase substrate diversification: structure and function analysis of HAD subclass IIB sugar phosphatase BT4131.

6 July 2018

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The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases

6 July 2018

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Characterization of the 4-Hydroxybenzoyl-Coenzyme A Thioesterase from Arthrobacter sp. Strain SU

6 July 2018

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Enterobactin: an archetype for microbial iron transport

6 July 2018

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Kinetic evidence for a substrate-induced fit in phosphonoacetaldehyde hydrolase catalysis

6 July 2018

1 reference

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X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase

6 July 2018

1 reference

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The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily

6 July 2018

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The relationship between protein structure and function: a comprehensive survey with application to the yeast genome

6 July 2018

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Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase

6 July 2018

1 reference

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Catalytic promiscuity and the evolution of new enzymatic activities

6 July 2018

1 reference

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Supersites within superfolds. Binding site similarity in the absence of homology.

6 July 2018

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Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate.

6 July 2018

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Structure, catalytic mechanism, and evolution of the glutathione transferases

6 July 2018

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A new enzyme superfamily - the phosphopantetheinyl transferases

6 July 2018

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Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase

6 July 2018

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Structural comparisons lead to the definition of a new superfamily of NAD(P)(H)-accepting oxidoreductases: the single-domain reductases/epimerases/dehydrogenases (the 'RED' family).

6 July 2018

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Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approach to database search

6 July 2018

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Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain

6 July 2018

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Ancestry of the 4-chlorobenzoate dehalogenase: analysis of amino acid sequence identities among families of acyl:adenyl ligases, enoyl-CoA hydratases/isomerases, and acyl-CoA thioesterases

6 July 2018

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Enzyme recruitment in evolution of new function

6 July 2018

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The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the alpha-protons of carboxylic acids

6 July 2018

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Beta1,4-N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase-sensitive, disulfide-bonded dimer by a cathepsin D-like protease

21 January 2018

1 reference

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Elucidation of a monovalent cation dependence and characterization of the divalent cation binding site of the fosfomycin resistance protein (FosA).

21 January 2018

1 reference

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Evolution of structure and function in the o-succinylbenzoate synthase/N-acylamino acid racemase family of the enolase superfamily

21 January 2018

1 reference

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Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family.

21 January 2018

1 reference

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Structure and activity analyses of Escherichia coli K-12 NagD provide insight into the evolution of biochemical function in the haloalkanoic acid dehalogenase superfamily

21 January 2018

1 reference

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Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA.

21 January 2018

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Revealing the hidden functional diversity of an enzyme family

21 January 2018

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The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo.

21 January 2018

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Structure, function, and mechanism of the phenylacetate pathway hot dog-fold thioesterase PaaI.

21 January 2018

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Structure-guided approach for detecting large domain inserts in protein sequences as illustrated using the haloacid dehalogenase superfamily.

21 January 2018

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Catalytic cycling in beta-phosphoglucomutase: a kinetic and structural analysis

21 January 2018

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Connectivity between catalytic landscapes of the metallo-β-lactamase superfamily

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25210039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Conformational Cycling in β-Phosphoglucomutase Catalysis: Reorientation of the β-d-Glucose 1,6-(Bis)phosphate Intermediate†

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25210039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Evolution of substrate diversity in the superfamily of amino acid dehydrogenases. Prospects for rational chiral synthesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25210039

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R114.572990

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25210039%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25210039%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference