Novel molecules that interact with microtubules and have functional activity similar to Taxol (Q34432179)

2 August 2017

title

Novel molecules that interact with microtubules and have functional activity similar to Taxol (English)

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2 August 2017

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3

Susan Band Horwitz

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2 August 2017

Lifeng He

1

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2 August 2017

George A. Orr

series ordinal

2

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2 August 2017

publication date

1 November 2001

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2 August 2017

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2 August 2017

volume

6

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2 August 2017

issue

22

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2 August 2017

page(s)

1153-1164

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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

2 August 2017

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Taxol binds to polymerized tubulin in vitro

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Low resolution structure of microtubules in solution. Synchrotron X-ray scattering and electron microscopy of taxol-induced microtubules assembled from purified tubulin in comparison with glycerol and MAP-induced microtubules

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Taxol stabilizes microtubules in mouse fibroblast cells

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Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

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7 January 2021

Direct photoaffinity labeling of tubulin with taxol

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7 January 2021

Characterization of the taxol binding site on the microtubule. 2-(m-Azidobenzoyl)taxol photolabels a peptide (amino acids 217-231) of beta-tubulin

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7 January 2021

Characterization of the Taxol Binding Site on the Microtubule

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7 January 2021

Structure of the alpha beta tubulin dimer by electron crystallography

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High-resolution model of the microtubule

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7 January 2021

The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density

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7 January 2021

How Taxol stabilises microtubule structure.

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7 January 2021

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7 January 2021

Tubulin and FtsZ form a distinct family of GTPases

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7 January 2021

Role of nucleotide hydrolysis in microtubule assembly

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7 January 2021

Guanosinetriphosphatase activity of tubulin associated with microtubule assembly

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7 January 2021

Interactions of tubulin with guanine nucleotides that have paclitaxel-like effects on tubulin assembly: 2',3'-dideoxyguanosine 5'-[alpha,beta-methylene]triphosphate, guanosine 5'-[alpha,beta-methylene]triphosphate, and 2',3'-dideoxyguanosine 5'-trip

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7 January 2021

Microtubule structure at improved resolution

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7 January 2021

P-glycoprotein and multidrug resistance

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From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance.

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7 January 2021

Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells

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7 January 2021

Synthesis and structure-activity relationships of new second-generation taxoids

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7 January 2021

Synthesis of highly potent second-generation taxoids through effective kinetic resolution coupling of racemic beta-lactams with baccatins

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Anti-proliferative activity of a new class of taxanes (14β-hydroxy-10-deacetylbaccatin III derivatives) on multidrug-resistance-positive human cancer cells

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7 January 2021

Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance

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7 January 2021

Tumor targeting by conjugation of DHA to paclitaxel

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7 January 2021

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

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Total Synthesis of(–)-Epothilone A

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7 January 2021

Synthesis of epothilones A and B in solid and solution phase

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7 January 2021

Cloning and heterologous expression of the epothilone gene cluster.

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7 January 2021

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

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7 January 2021

The synthesis, discovery, and development of a highly promising class of microtubule stabilization agents: curative effects of desoxyepothilones B and F against human tumor xenografts in nude mice

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7 January 2021

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

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7 January 2021

The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

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7 January 2021

Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules

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7 January 2021

The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation

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7 January 2021

Immunosuppression by discodermolide.

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7 January 2021

(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

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7 January 2021

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

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7 January 2021

The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

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7 January 2021

The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies

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7 January 2021

Distinct binding and cellular properties of synthetic (+)- and (-)-discodermolides

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7 January 2021

Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity

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7 January 2021

Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity

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7 January 2021

Gram-scale synthesis of (+)-discodermolide

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7 January 2021

Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubules

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7 January 2021

The coral-derived natural products eleutherobin and sarcodictyins A and B: effects on the assembly of purified tubulin with and without microtubule-associated proteins and binding at the polymer taxoid site.

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7 January 2021

Structure-activity profiles of eleutherobin analogs and their cross-resistance in Taxol-resistant cell lines

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7 January 2021

A common pharmacophore for cytotoxic natural products that stabilize microtubules

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7 January 2021

A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone

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7 January 2021

A Common Pharmacophore for Taxol and the Epothilones Based on the Biological Activity of a Taxane Molecule Lacking a C-13 Side Chain†

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7 January 2021

Solution structure of (+)-discodermolide

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7 January 2021

The conformations of discodermolide in DMSO.

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7 January 2021

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

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7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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7 January 2021

Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations

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7 January 2021

10.1016/S1359-6446(01)02038-4

Identifiers

DOI

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2 August 2017

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