Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease (Q34443935)

2 August 2017

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title

Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease (English)

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2 August 2017

Sarah L Miles

1

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PubMed ID

25323953

2 August 2017

Margaret McFarland

series ordinal

2

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PubMed ID

25323953

2 August 2017

Richard M Niles

series ordinal

3

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2 August 2017

16 October 2014

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2 August 2017

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2 August 2017

72

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2 August 2017

11

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2 August 2017

720-734

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Flavonoid-Peroxidase Reaction as a Detoxification Mechanism of Plant Cells against H2O2.

2 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin pharmacokinetics in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Stabilization of p53 is involved in quercetin-induced cell cycle arrest and apoptosis in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Regulation of survivin and Bcl-2 in HepG2 cell apoptosis induced by quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Essential role of Nrf2 in keratinocyte protection from UVA by quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

The pro-apoptotic effect of quercetin in cancer cell lines requires ERβ-dependent signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

The dietary bioflavonoid, quercetin, selectively induces apoptosis of prostate cancer cells by down-regulating the expression of heat shock protein 90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin glucuronide inhibits cell migration and proliferation by platelet-derived growth factor in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin modulates NF-kappa B and AP-1/JNK pathways to induce cell death in human hepatoma cells.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Inhibition of angiotesin-converting enzyme by quercetin alters the vascular response to brandykinin and angiotensin I.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Topoisomerase II inhibition and high yield of endoreduplication induced by the flavonoids luteolin and quercetin.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

hTERT: another brick in the wall of cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin: A novel inhibitors of Ca2+ influx and exocytosis in rat peritoneal mast cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin inhibition of the induction and function of cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin, flavonoids and the life-span of mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Anti-ageing and rejuvenating effects of quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin's influence on exercise performance and muscle mitochondrial biogenesis

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Effects of quercetin supplementation on endurance performance and maximal oxygen consumption: a meta-analysis

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Diabetic Cataracts and Flavonoids

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Antidiabetic effects of quercetin in streptozocin-induced diabetic rats

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice.

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin potentiates insulin secretion and protects INS-1 pancreatic β-cells against oxidative damage via the ERK1/2 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin inhibits lymphocyte activation and proliferation without inducing apoptosis in peripheral mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Effect of quercetin on impaired immune function in mice exposed to irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Reversal of aging and chronic ethanol-induced cognitive dysfunction by quercetin a bioflavonoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Meta-Analysis of Global Transcriptomics Suggests that Conserved Genetic Pathways are Responsible for Quercetin and Tannic Acid Mediated Longevity in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Flavonols and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Flavonoid intake and coronary mortality in Finland: a cohort study

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Rutin and quercetin show greater efficacy than nifedipin in ameliorating hemodynamic, redox, and metabolite imbalances in sodium chloride-induced hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin: a potential drug to reverse multidrug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Lack of p53 mutations and loss of heterozygosity in non-cultured human melanocytic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin increases the efficacy of glioblastoma treatment compared to standard chemoradiotherapy by the suppression of PI-3-kinase-Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

Inhibition of angiotensin converting enzyme (ACE) by flavonoids isolated fromAilanthus excelsa (Roxb) (Simaroubaceae)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNURE.12152

21 January 2018

Identifiers

DOI

10.1111/NURE.12152

1 reference

2 August 2017

1 reference

PubMed ID

25323953