Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim (Q34450473)

2 August 2017

title

Maximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim (English)

1 reference

2 August 2017

0 references

Marco J Herold

6

0 references

Mark S Cragg

Mark S Cragg

2

0 references

Suzanne Cory

Suzanne Cory

12

0 references

Gordon K Smyth

Gordon K Smyth

10

0 references

Andreas Strasser

Andreas Strasser

11

0 references

Belinda Phipson

3

Belinda Phipson

1 reference

2 August 2017

Ewa M Michalak

8

0 references

Grant Dewson

Grant Dewson

7

0 references

Clare L Scott

Clare L Scott

13

0 references

author name string

Lina Happo

1

1 reference

2 August 2017

Jon M Haga

4

1 reference

2 August 2017

Elisa S Jansen

5

1 reference

2 August 2017

Cassandra J Vandenberg

9

1 reference

2 August 2017

language of work or name

English

0 references

publication date

9 September 2010

1 reference

2 August 2017

1 reference

2 August 2017

volume

116

1 reference

2 August 2017

issue

24

1 reference

2 August 2017

page(s)

5256-5267

1 reference

An essential role for p73 in regulating mitotic cell death

2 August 2017

cites work

1 reference

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Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics

6 July 2018

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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

6 July 2018

1 reference

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In vivo efficacy of the Bcl-2 antagonist ABT-737 against aggressive Myc-driven lymphomas

6 July 2018

1 reference

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Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

6 July 2018

1 reference

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FOXOs, cancer and regulation of apoptosis

6 July 2018

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

6 July 2018

1 reference

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In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

6 July 2018

1 reference

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FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

6 July 2018

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

6 July 2018

1 reference

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ER stress triggers apoptosis by activating BH3-only protein Bim

6 July 2018

1 reference

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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

6 July 2018

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Role of the chromobox protein CBX7 in lymphomagenesis.

6 July 2018

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The Bcl-2 apoptotic switch in cancer development and therapy

6 July 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

6 July 2018

1 reference

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

6 July 2018

1 reference

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Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells.

6 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

6 July 2018

1 reference

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A global map of p53 transcription-factor binding sites in the human genome

6 July 2018

1 reference

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Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

6 July 2018

1 reference

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BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

6 July 2018

1 reference

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Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

6 July 2018

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Polycystic kidney disease prevented by transgenic RNA interference

6 July 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

6 July 2018

1 reference

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Bim is a suppressor of Myc-induced mouse B cell leukemia

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray

6 July 2018

1 reference

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

6 July 2018

1 reference

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

6 July 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

6 July 2018

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Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes

6 July 2018

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BH3-Only proteins-essential initiators of apoptotic cell death

6 July 2018

1 reference

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

6 July 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

6 July 2018

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Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L)

6 July 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Abrogation of p53 function affects gadd gene responses to DNA base-damaging agents and starvation

6 July 2018

1 reference

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Tumor spectrum analysis in p53-mutant mice

6 July 2018

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The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Myc oncogene activation in B and T lymphoid tumours.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Control of c-myc regulation in normal and neoplastic cells.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

Genetic analysis of chemoresistance in primary murine lymphomas.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012543

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20829369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20829369

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2010-04-280818

1 reference

release_ehxb36yknvh4blb7bba3dwoiqy

2 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ehxb36yknvh4blb7bba3dwoiqy

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

3012543

1 reference

2 August 2017

1 reference