Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus (Q34455805)

25542975

2 August 2017

title

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus (English)

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25542975

Middle East respiratory syndrome coronavirus

2 August 2017

main subject

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Middle East

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6-thioguanine

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Middle East respiratory syndrome

ChEBI release 2020-05-28

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3

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12 June 2020

Chi-Yuan Chou

8

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12 June 2020

author name string

Kai-Wen Cheng

1

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12 June 2020

Shu-Chun Cheng

2

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12 June 2020

Min-Han Lin

4

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12 June 2020

Shang-Ju Chuang

5

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12 June 2020

I-Hsin Cheng

6

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12 June 2020

Chiao-Yin Sun

7

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12 June 2020

publication date

24 December 2014

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2 August 2017

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12 June 2020

volume

115

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12 June 2020

page(s)

9-16

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Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

12 June 2020

cites work

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Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression

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Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease

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The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

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Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

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Cellular IMPDH enzyme activity is a potential target for the inhibition of Chikungunya virus replication and virus induced apoptosis in cultured mammalian cells

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Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme

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Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

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Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

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Severe Acute Respiratory Syndrome Coronavirus Papain-like Novel Protease Inhibitors: Design, Synthesis, Protein−Ligand X-ray Structure and Biological Evaluation

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Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease

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Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

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Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA.

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A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

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Structural and functional characterization of MERS coronavirus papain-like protease

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Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

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Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

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Antiviral or proviral action of mycophenolic acid in hepatitis B infection?

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Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases.

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Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa

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Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

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DNA inhibits catalysis by the carboxyltransferase subunit of acetyl-CoA carboxylase: implications for active site communication.

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Aprotinin and similar protease inhibitors as drugs against influenza

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The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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Mycophenolic acid inhibits replication of Japanese encephalitis virus

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Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63

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PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production

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Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.

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Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

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Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications

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In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection

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Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial

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Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer

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Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

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12 December 2020

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

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12 December 2020

10.1016/J.ANTIVIRAL.2014.12.011

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12 June 2020

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12 June 2020

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