Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features (Q27694423)

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3

Christian Drosten

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6

Rolf Hilgenfeld

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author name string

Jeroen R Mesters

series ordinal

2

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11 June 2020

Stefan Anemüller

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4

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11 June 2020

Qingjun Ma

series ordinal

5

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11 June 2020

publication date

September 2014

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published in

Antiviral Research

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volume

109

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page(s)

72-82

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Structural basis of ubiquitin recognition by the deubiquitinating protease USP2

11 June 2020

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Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease

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Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

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Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease

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MERS-CoV papain-like protease has deISGylating and deubiquitinating activities

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The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

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The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

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pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses

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Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular Substrates

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Structure of the SARS coronavirus main proteinase as an active C2 crystallographic dimer

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A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication

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Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling

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Assessing activity and inhibition of Middle East respiratory syndrome coronavirus papain-like and 3C-like proteases using luciferase-based biosensors

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Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution

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Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation

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12 December 2020

In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection

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12 December 2020

Structural determinants for the binding of ubiquitin-like domains to the proteasome

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12 December 2020

10.1016/J.ANTIVIRAL.2014.06.011

Identifiers

DOI

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