The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene (Q34462232)

2 August 2017

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene (English)

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2 August 2017

René Bernards

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Daniel Peeper

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3

object named as

Daniel S Peeper

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2 August 2017

Benjamin D Rowland

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2 August 2017

1 November 2005

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7

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11

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1074-1082

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https://scigraph.springernature.com/pub.10.1038/ncb1314

2 August 2017

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cites work

Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest

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7 January 2021

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

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7 January 2021

Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation

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7 January 2021

Krüppel-like factor 4 (gut-enriched Krüppel-like factor) inhibits cell proliferation by blocking G1/S progression of the cell cycle

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7 January 2021

Transactivation and growth suppression by the gut-enriched Krüppel-like factor (Krüppel-like factor 4) are dependent on acidic amino acid residues and protein-protein interaction

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7 January 2021

The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter

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7 January 2021

Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier

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7 January 2021

Klf4 is a transcription factor required for establishing the barrier function of the skin

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7 January 2021

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

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7 January 2021

Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

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7 January 2021

Expression of the gut-enriched Krüppel-like factor (Krüppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2.

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7 January 2021

Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients

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7 January 2021

Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis

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7 January 2021

Role of gut-enriched Krüppel-like factor in colonic cell growth and differentiation

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7 January 2021

Identification of Krüppel-like factor 4 as a potential tumor suppressor gene in colorectal cancer

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7 January 2021

Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression

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7 January 2021

Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach

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7 January 2021

Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity

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7 January 2021

Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia

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7 January 2021

p19ARF links the tumour suppressor p53 to Ras

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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7 January 2021

Escape from premature senescence is not sufficient for oncogenic transformation by Ras.

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7 January 2021

The RB and p53 pathways in cancer

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7 January 2021

A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

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7 January 2021

Stable suppression of tumorigenicity by virus-mediated RNA interference

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7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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7 January 2021

The critical role of the PE21 element in oncostatin M-mediated transcriptional repression of the p53 tumor suppressor gene in breast cancer cells

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7 January 2021

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

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7 January 2021

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

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7 January 2021

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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7 January 2021

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

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7 January 2021

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

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7 January 2021

Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect

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7 January 2021

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

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7 January 2021

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells

1 reference

7 January 2021

Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells

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7 January 2021

E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

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7 January 2021

Transactivation of the human keratin 4 and Epstein-Barr virus ED-L2 promoters by gut-enriched Krüppel-like factor

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7 January 2021

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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7 January 2021

Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53.

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7 January 2021

Compromised HOXA5 function can limit p53 expression in human breast tumours

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7 January 2021

Identifiers

DOI

10.1038/NCB1314

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PubMed ID

16244670

Dimensions Publication ID

2 August 2017

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1 reference

PubMed ID

16244670