Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis (Q34468358)

2 August 2017

title

Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis (English)

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2 August 2017

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Pu Wang

2

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Sudarshan Anand

object named as

Sudarshan Anand

1

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Andrew S. Flies

object named as

Andrew S Flies

9

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Richard D Schulick

8

object named as

Richard Schulick

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2 August 2017

13

Drew M Pardoll

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2 August 2017

Kiyoshi Yoshimura

3

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2 August 2017

In-Hak Choi

4

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2 August 2017

Anja Hilliard

5

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2 August 2017

Youhai H Chen

6

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2 August 2017

Chyung-Ru Wang

7

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2 August 2017

Dallas B Flies

10

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2 August 2017

Gefeng Zhu

11

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2 August 2017

Yanhui Xu

12

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2 August 2017

Lieping Chen

14

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2 August 2017

Koji Tamada

15

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2 August 2017

language of work or name

English

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publication date

23 March 2006

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Journal of Clinical Investigation

2 August 2017

published in

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2 August 2017

volume

116

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2 August 2017

issue

4

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2 August 2017

page(s)

1045-1051

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The role of herpesvirus entry mediator as a negative regulator of T cell-mediated responses

2 August 2017

cites work

1 reference

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B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

6 July 2018

1 reference

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Lymphotoxin and LIGHT signaling pathways and target genes

6 July 2018

1 reference

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To be or not to be NKT: natural killer T cells in the liver.

6 July 2018

1 reference

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Immune responses to Listeria monocytogenes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Dysregulated LIGHT expression on T cells mediates intestinal inflammation and contributes to IgA nephropathy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Critical roles of TRAIL in hepatic cell death and hepatic inflammation.

6 July 2018

1 reference

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Death Receptor Activation-Induced Hepatocyte Apoptosis and Liver Injury

6 July 2018

1 reference

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Signalling pathways of the TNF superfamily: a double-edged sword

6 July 2018

1 reference

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Upregulation of lymphotoxin beta expression in liver progenitor (oval) cells in chronic hepatitis C.

6 July 2018

1 reference

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Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis

6 July 2018

1 reference

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LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Modulation of LIGHT-HVEM costimulation prolongs cardiac allograft survival

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

6 July 2018

1 reference

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The regulation of T cell homeostasis and autoimmunity by T cell-derived LIGHT

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Tumor necrosis factor receptor superfamily 14 is involved in atherogenesis by inducing proinflammatory cytokines and matrix metalloproteinases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation, and tissue destruction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Genomic characterization of LIGHT reveals linkage to an immune response locus on chromosome 19p13.3 and distinct isoforms generated by alternate splicing or proteolysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Critical contribution of liver natural killer T cells to a murine model of hepatitis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Discrete signaling regions in the lymphotoxin-beta receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-kappaB pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

A T cell-dependent experimental liver injury in mice inducible by concanavalin A

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Invariant V alpha 14+ NKT cells participate in the early response to enteric Listeria monocytogenes infection.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

CD1d-independent regulation of NKT cell migration and cytokine production upon Listeria monocytogenes infection

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

LIGHT is involved in the pathogenesis of rheumatoid arthritis by inducing the expression of pro-inflammatory cytokines and MMP-9 in macrophages.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

The role of apoptosis signal-regulating kinase 1 in lymphotoxin-beta receptor-mediated cell death.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1409742

Contribution of the Lymphotoxin Receptor to Liver Regeneration

27 October 2018

1 reference

12 December 2020

LIGHT, a TNF-like molecule, costimulates T cell proliferation and is required for dendritic cell-mediated allogeneic T cell response

1 reference

12 December 2020

Fas engagement accelerates liver regeneration after partial hepatectomy

1 reference

12 December 2020

Overexpression of bcl-2 enhances LIGHT- and interferon-gamma -mediated apoptosis in Hep3BT2 cells

1 reference

12 December 2020

Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures

1 reference

12 December 2020

Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

1 reference

12 December 2020

Hydrodynamic delivery of DNA

1 reference

12 December 2020

Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity

1 reference

12 December 2020

Early production of IL-4 and induction of Th2 responses in the lymph node originate from an MHC class I-independent CD4+NK1.1- T cell population

1 reference

12 December 2020

Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice

1 reference

12 December 2020

Mechanism of LIGHT/interferon-?-induced cell death in HT-29 cells

1 reference

12 December 2020

The Critical Role of LIGHT in Promoting Intestinal Inflammation and Crohn's Disease

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI27083

1 reference

2 August 2017

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2 August 2017

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