Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. (Q34471813)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25202140%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis (English)

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16 February 2020

14

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16 February 2020

Philip J Lupo

15

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16 February 2020

Kenneth L McClain

22

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16 February 2020

21

Miriam Merad

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16 February 2020

11

Donna M Muzny

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16 February 2020

author name string

Rikhia Chakraborty

1

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16 February 2020

Oliver A Hampton

2

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16 February 2020

Xiaoyun Shen

3

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16 February 2020

Stephen J Simko

4

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16 February 2020

Albert Shih

5

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16 February 2020

Harshal Abhyankar

6

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16 February 2020

Karen Phaik Har Lim

7

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16 February 2020

Kyle R Covington

8

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Lisa Trevino

9

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16 February 2020

Ninad Dewal

10

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16 February 2020

Harshavardhan Doddapaneni

12

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16 February 2020

Jianhong Hu

13

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16 February 2020

M John Hicks

16

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16 February 2020

Diana L Bonilla

17

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16 February 2020

Karen C Dwyer

18

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Marie-Luise Berres

19

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Poulikos I Poulikakos

20

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David A Wheeler

23

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16 February 2020

Carl E Allen

24

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D Williams Parsons

25

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language of work or name

English

0 references

publication date

8 September 2014

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16 February 2020

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16 February 2020

volume

124

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16 February 2020

issue

19

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16 February 2020

page(s)

3007-3015

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Somatic activating ARAF mutations in Langerhans cell histiocytosis.

16 February 2020

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BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

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Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases

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6 July 2018

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B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease

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Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations

6 July 2018

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Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

6 July 2018

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

6 July 2018

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Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities

6 July 2018

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Benchmarking of mutation diagnostics in clinical lung cancer specimens

6 July 2018

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Resistance to MEK inhibitors: should we co-target upstream?

6 July 2018

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COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

6 July 2018

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Recurrent BRAF mutations in Langerhans cell histiocytosis

6 July 2018

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Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells

6 July 2018

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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27 October 2018

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Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

27 October 2018

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27 October 2018

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12 December 2020

No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies

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12 December 2020

AnNRASmutation in a case of Erdheim-Chester disease

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12 December 2020

A phase IIa study of afuresertib, an oral pan-AKT inhibitor, in patients with Langerhans cell histiocytosis.

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12 December 2020

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Identifiers

DOI

1 reference

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16 February 2020

1 reference

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16 February 2020

1 reference

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