Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations (Q34475657)

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English	Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations	scientific article

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17 February 2020

Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutations (English)

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17 February 2020

Jeyakumar Kandasamy

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17 February 2020

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Dana Atia-Glikin

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17 February 2020

Eli Shulman

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17 February 2020

Katya Shapira

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17 February 2020

Michal Shavit

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17 February 2020

Valery Belakhov

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17 February 2020

Timor Baasov

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17 February 2020

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29 November 2012

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17 February 2020

Journal of Medicinal Chemistry

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17 February 2020

55

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17 February 2020

23

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17 February 2020

10630-10643

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17 February 2020

A comparative evaluation of NB30, NB54 and PTC124 in translational read-through efficacy for treatment of an USH1C nonsense mutation

1 reference

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The structure of the eukaryotic ribosome at 3.0 Å resolution

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The designer aminoglycoside NB84 significantly reduces glycosaminoglycan accumulation associated with MPS I-H in the Idua-W392X mouse

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6 July 2018

Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

1 reference

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Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells

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Suppression of CFTR premature termination codons and rescue of CFTR protein and function by the synthetic aminoglycoside NB54

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6 July 2018

Ex vivo treatment with a novel synthetic aminoglycoside NB54 in primary fibroblasts from Rett syndrome patients suppresses MECP2 nonsense mutations

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Readthrough of nonsense mutations in Rett syndrome: evaluation of novel aminoglycosides and generation of a new mouse model

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6 July 2018

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations

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Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases

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Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria

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6 July 2018

Differential selectivity of natural and synthetic aminoglycosides towards the eukaryotic and prokaryotic decoding A sites

1 reference

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6 July 2018

In vitro and ex vivo suppression by aminoglycosides of PCDH15 nonsense mutations underlying type 1 Usher syndrome

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Aminoglycoside-induced translational read-through in disease: overcoming nonsense mutations by pharmacogenetic therapy

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6 July 2018

Comparison of cytotoxicity of aminoglycoside antibiotics using a panel cellular biotest system

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Structural basis for selectivity and toxicity of ribosomal antibiotics

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Gentamicin-mediated suppression of Hurler syndrome stop mutations restores a low level of alpha-L-iduronidase activity and reduces lysosomal glycosaminoglycan accumulation

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Aminoglycoside antibiotics mediate context-dependent suppression of termination codons in a mammalian translation system

1 reference

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Redesign of aminoglycosides for treatment of human genetic diseases caused by premature stop mutations

1 reference

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1 reference

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1 reference

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When running a stop sign may be a good thing

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM3012992

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17 February 2020

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17 February 2020

1 reference

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17 February 2020

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