Engineered CRISPR-Cas9 nucleases with altered PAM specificities (Q34481737)

2 August 2017

title

Engineered CRISPR-Cas9 nucleases with altered PAM specificities (English)

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2 August 2017

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Benjamin P Kleinstiver

object named as

Benjamin P Kleinstiver

1

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Zongli Zheng

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Zongli Zheng

6

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Martin J. Aryee

11

object named as

Martin J Aryee

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2 August 2017

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J Keith Joung

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2 August 2017

Michelle S Prew

2

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2 August 2017

Shengdar Q Tsai

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2 August 2017

Ved V Topkar

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2 August 2017

Nhu T Nguyen

5

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2 August 2017

Andrew P W Gonzales

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2 August 2017

Zhuyun Li

8

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2 August 2017

Randall T Peterson

9

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2 August 2017

Jing-Ruey Joanna Yeh

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2 August 2017

language of work or name

English

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publication date

22 June 2015

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2 August 2017

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2 August 2017

volume

523

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2 August 2017

issue

7561

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2 August 2017

page(s)

481-485

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In vivo genome editing using Staphylococcus aureus Cas9

2 August 2017

cites work

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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

6 July 2018

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Genome editing. The new frontier of genome engineering with CRISPR-Cas9

6 July 2018

1 reference

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Saturation editing of genomic regions by multiplex homology-directed repair

6 July 2018

1 reference

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Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4540238

Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4540238

Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs

6 July 2018

1 reference

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Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

6 July 2018

1 reference

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Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

6 July 2018

1 reference

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CRISPR-Cas systems for editing, regulating and targeting genomes

6 July 2018

1 reference

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DNA interrogation by the CRISPR RNA-guided endonuclease Cas9.

6 July 2018

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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

6 July 2018

1 reference

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Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

6 July 2018

1 reference

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Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

6 July 2018

1 reference

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

6 July 2018

1 reference

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Optimization of scarless human stem cell genome editing

6 July 2018

1 reference

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CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

6 July 2018

1 reference

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DNA targeting specificity of RNA-guided Cas9 nucleases

6 July 2018

1 reference

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

6 July 2018

1 reference

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The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems

6 July 2018

1 reference

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Protospacer recognition motifs: mixed identities and functional diversity

6 July 2018

1 reference

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RNA-guided editing of bacterial genomes using CRISPR-Cas systems

6 July 2018

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Efficient genome editing in zebrafish using a CRISPR-Cas system

6 July 2018

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RNA-guided human genome engineering via Cas9

6 July 2018

1 reference

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Multiplex genome engineering using CRISPR/Cas systems

6 July 2018

1 reference

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

6 July 2018

1 reference

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FLASH assembly of TALENs for high-throughput genome editing

6 July 2018

1 reference

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A unified genetic, computational and experimental framework identifies functionally relevant residues of the homing endonuclease I-BmoI.

6 July 2018

1 reference

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Fast and accurate short read alignment with Burrows-Wheeler transform

6 July 2018

1 reference

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Short motif sequences determine the targets of the prokaryotic CRISPR defence system

6 July 2018

1 reference

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Phage response to CRISPR-encoded resistance in Streptococcus thermophilus

6 July 2018

1 reference

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Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus

6 July 2018

1 reference

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Directed evolution and substrate specificity profile of homing endonuclease I-SceI.

6 July 2018

1 reference

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A highly sensitive selection method for directed evolution of homing endonucleases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4540238

Initial sequencing and analysis of the human genome

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4540238

Gene conversion tracts from double-strand break repair in mammalian cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4540238

6 July 2018

Identifiers

DOI

10.1038/NATURE14592

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Dimensions Publication ID

2 August 2017

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2 August 2017

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