HSP90 as a new therapeutic target for cancer therapy: the story unfolds (Q34482045)

2 August 2017

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title

HSP90 as a new therapeutic target for cancer therapy: the story unfolds (English)

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2 August 2017

2

Paul Workman

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2 August 2017

Alison Maloney

1

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PubMed ID

11772336

2 August 2017

language of work or name

English

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publication date

1 January 2002

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Expert Opinion on Biological Therapy

2 August 2017

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2 August 2017

2

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2 August 2017

1

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2 August 2017

3-24

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Role of the heat shock response and molecular chaperones in oncogenesis and cell death

2 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Heat shock proteins: new keys to the development of cytoprotective therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Do heat shock proteins have a role in breast cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Clinical and biological significance of HSP89 alpha in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

New drug targets for genomic cancer therapy: successes, limitations, opportunities and future challenges.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Scoring a bull's-eye against cancer genome targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Discovering novel chemotherapeutic drugs for the third millennium

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Hsp90: a specialized but essential protein-folding tool

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Hsp90 as a capacitor for morphological evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The molecular chaperones Hsp90 and Hsc70 are both necessary and sufficient to activate hormone binding by glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Progesterone receptor structure and function altered by geldanamycin, an hsp90-binding agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The hsp90-based chaperone system: involvement in signal transduction from a variety of hormone and growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Regulation of Pim-1 by Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Localization of HSP90 binding sites in the human hepatitis B virus polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Heat shock proteins 70 and 90 increase calcineurin activity in vitro through calmodulin-dependent and independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Apoprotein B degradation is promoted by the molecular chaperones hsp90 and hsp70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein - The role of hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

GRP94, an ER chaperone with protein and peptide binding properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The Hsp90 complex--a super-chaperone machine as a novel drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Structure and in vivo function of Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor tyrosine kinase in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Function of 90-kDa heat shock protein in cellular differentiation of human embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Proliferation, cell cycle and apoptosis in cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Checking out the G(2)/M transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Control of the cell cycle and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Cell-cycle arrest and p53 accumulation induced by geldanamycin in human ovarian tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Escaping cell death: survival proteins in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Angiogenesis in cancer and other diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Over-expression of heat shock proteins in carcinogenic endometrium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Genetic interactions between Hsp90 and the Cdc2 mitotic machineryin the fission yeast Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14712598.2.1.3

21 January 2018

Identifiers

DOI

10.1517/14712598.2.1.3

1 reference

2 August 2017

1 reference

PubMed ID

11772336