Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content (Q34483105)

2 August 2017

Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content (English)

1 reference

2 August 2017

1 reference

Hanna Appelqvist

1

1 reference

2 August 2017

Linnea Sandin

2

1 reference

2 August 2017

Karin Björnström

3

1 reference

2 August 2017

Paul Saftig

4

1 reference

2 August 2017

Brett Garner

5

1 reference

2 August 2017

Karin Ollinger

6

1 reference

2 August 2017

Katarina Kågedal

7

1 reference

2 August 2017

language of work or name

English

0 references

publication date

16 November 2012

1 reference

2 August 2017

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2 August 2017

7

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2 August 2017

11

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2 August 2017

e50262

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Creative Commons Attribution 4.0 International

2 August 2017

start time

16 November 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Lysosomes and lysosomal cathepsins in cell death

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Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation

6 July 2018

1 reference

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Lysosomal membrane proteins: life between acid and neutral conditions

6 July 2018

1 reference

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Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization

6 July 2018

1 reference

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Selective cell death in neurodegeneration: why are some neurons spared in vulnerable regions?

6 July 2018

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Pathophysiology of neuropathic lysosomal storage disorders

6 July 2018

1 reference

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Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect

6 July 2018

1 reference

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Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells

6 July 2018

1 reference

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Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition

6 July 2018

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Regulation of apoptosis-associated lysosomal membrane permeabilization

6 July 2018

1 reference

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Lipids on trial: the search for the offending metabolite in Niemann-Pick type C disease

6 July 2018

1 reference

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Lipid rafts as a membrane-organizing principle

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Niemann-Pick C1 functions independently of Niemann-Pick C2 in the initial stage of retrograde transport of membrane-impermeable lysosomal cargo

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid

6 July 2018

1 reference

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Role for LAMP-2 in endosomal cholesterol transport

6 July 2018

1 reference

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Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice

6 July 2018

1 reference

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Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

6 July 2018

1 reference

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Niemann-Pick C1 functions in regulating lysosomal amine content

6 July 2018

1 reference

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Neurodegenerative lysosomal disorders: a continuum from development to late age.

6 July 2018

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Drug-induced phospholipidosis

6 July 2018

1 reference

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Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Sphingomyelins suppress the targeted disruption of lysosomes/endosomes by the photosensitizer NPe6 during photodynamic therapy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts

6 July 2018

1 reference

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Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons

6 July 2018

1 reference

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Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis.

6 July 2018

1 reference

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Sphingosine-induced apoptosis is dependent on lysosomal proteases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

6 July 2018

1 reference

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How cells handle cholesterol.

6 July 2018

1 reference

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Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

6 July 2018

1 reference

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Induction of cell death by the lysosomotropic detergent MSDH.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Type C Niemann-Pick disease. Lysosomal accumulation and defective intracellular mobilization of low density lipoprotein cholesterol.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Photooxidative damage to lysosomes of cultured macrophages by acridine orange

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

Microinjection of cathepsin d induces caspase-dependent apoptosis in fibroblasts

6 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050262

Lysobisphosphatidic acid controls endosomal cholesterol levels

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050262

Adaptation of neuronal cells to chronic oxidative stress is associated with altered cholesterol and sphingolipid homeostasis and lysosomal function

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0050262

Treatment with miglustat reverses the lipid-trafficking defect in Niemann-Pick disease type C.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3500374

The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23166840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23166840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0050262

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference