Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice (Q34483533)

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English	Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice	scientific article

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Europe PubMed Central

2 August 2017

Activation of EGFR, HER2 and HER3 by neurotensin/neurotensin receptor 1 renders breast tumors aggressive yet highly responsive to lapatinib and metformin in mice (English)

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Europe PubMed Central

2 August 2017

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3 June 2020

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3 June 2020

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Sandra Dupouy

1

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3 June 2020

Van Kien Doan

2

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3 June 2020

Najat Mourra

4

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3 June 2020

Jin Liu

5

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3 June 2020

Olivier De Wever

6

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3 June 2020

Frédérique Penault Llorca

7

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3 June 2020

Amal Kouchkar

9

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3 June 2020

Anne Gompel

10

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3 June 2020

Patricia Forgez

11

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3 June 2020

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1 September 2014

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2 August 2017

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3 June 2020

5

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3 June 2020

18

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3 June 2020

8235-8251

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3 June 2020

Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226680

6 July 2018

Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226680

6 July 2018

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells

1 reference

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6 July 2018

Neurotensin and its high affinity receptor 1 as a potential pharmacological target in cancer therapy

1 reference

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6 July 2018

Cancer statistics, 2013

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6 July 2018

Structure of the agonist-bound neurotensin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226680

6 July 2018

HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling

1 reference

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6 July 2018

Lapatinib, trastuzumab or the combination added to preoperative chemotherapy for breast cancer: a meta-analysis of randomized evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4226680

6 July 2018

Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells.

1 reference

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6 July 2018

Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells

1 reference

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6 July 2018

In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer

1 reference

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6 July 2018

The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers

1 reference

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6 July 2018

Global cancer statistics

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6 July 2018

Neurotensin receptor 1 determines the outcome of non-small cell lung cancer

1 reference

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6 July 2018

Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy

1 reference

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6 July 2018

Modeling and quantification of cancer cell invasion through collagen type I matrices

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6 July 2018

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth

1 reference

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6 July 2018

Quantitative multiplexed analysis of ErbB family coexpression for primary breast cancer prognosis in a large retrospective cohort

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6 July 2018

The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression

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6 July 2018

Her2-positive breast cancer: herceptin and beyond.

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6 July 2018

Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells

1 reference

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6 July 2018

Neurotensin stimulates mitogenesis of prostate cancer cells through a novel c-Src/Stat5b pathway

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6 July 2018

Expression of neurotensin and NT1 receptor in human breast cancer: a potential role in tumor progression

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6 July 2018

Neuregulins 1-4 are expressed in the cytoplasm or nuclei of ductal carcinoma (in situ) of the human breast

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6 July 2018

The inhibitory effect of ErbB2 on epidermal growth factor-induced formation of clathrin-coated pits correlates with retention of epidermal growth factor receptor-ErbB2 oligomeric complexes at the plasma membrane

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6 July 2018

Co-expression of neuregulins 1, 2, 3 and 4 in human breast cancer.

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Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

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6 July 2018

Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation

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6 July 2018

Neurotensin counteracts apoptosis in breast cancer cells

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6 July 2018

The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing

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6 July 2018

Endocytosis deficiency of epidermal growth factor (EGF) receptor-ErbB2 heterodimers in response to EGF stimulation

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6 July 2018

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

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6 July 2018

Alternative intracellular routing of ErbB receptors may determine signaling potency

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6 July 2018

Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms.

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6 July 2018

All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired

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6 July 2018

Plasma concentration of neurotensin-like immunoreactivity (NTLI) and lower esophageal sphincter (LES) pressure in man following infusion of (Gln4)-neurotensin

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6 July 2018

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes

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The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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6 July 2018

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6 July 2018

Neurotensin. Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone

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HER3 overexpression and survival in solid tumors: a meta-analysis

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Plasma proneurotensin and incidence of diabetes, cardiovascular disease, breast cancer, and mortality.

1 reference

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27 October 2018

Prolonged EGFR signaling by ERBB2-mediated sequestration at the plasma membrane

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27 October 2018

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27 October 2018

Increased concentrations of growth factors and activation of the EGFR system in breast cancer

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12 December 2020

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Neurotensin-amplification of DNA synthesis stimulated by EGF or TGF alpha in primary cultures of adult rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25249538

12 December 2020

based on heuristic

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Characterization of the metabolic turnover of epidermal growth factor receptor protein in A-431 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25249538

12 December 2020

based on heuristic

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Identifiers

10.18632/ONCOTARGET.1632

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25249538%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25249538%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25249538%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

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