Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes (Q34490485)

2 August 2017

title

Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes (English)

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2 August 2017

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Mojgan Rastegar

4

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author name string

Robby M Zachariah

series ordinal

1

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2 August 2017

Carl O Olson

series ordinal

2

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2 August 2017

Chinelo Ezeonwuka

series ordinal

3

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2 August 2017

language of work or name

English

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publication date

19 November 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

11

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2 August 2017

page(s)

e49763

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

19 November 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Methyl CpG-binding protein isoform MeCP2_e2 is dispensable for Rett syndrome phenotypes but essential for embryo viability and placenta development

6 July 2018

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MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

6 July 2018

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Transgenic complementation of MeCP2 deficiency: phenotypic rescue of Mecp2-null mice by isoform-specific transgenes

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Adult neural function requires MeCP2.

6 July 2018

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Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

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6 July 2018

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Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities

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Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions

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MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome

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Deletion of Mecp2 in Sim1-expressing neurons reveals a critical role for MeCP2 in feeding behavior, aggression, and the response to stress.

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Reversal of neurological defects in a mouse model of Rett syndrome

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Partial rescue of MeCP2 deficiency by postnatal activation of MeCP2.

6 July 2018

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Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

6 July 2018

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Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice

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A previously unidentified MECP2 open reading frame defines a new protein isoform relevant to Rett syndrome

6 July 2018

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The major form of MeCP2 has a novel N-terminus generated by alternative splicing

6 July 2018

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6 July 2018

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Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

6 July 2018

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6 July 2018

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6 July 2018

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

6 July 2018

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6 July 2018

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

6 July 2018

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A critical temporal requirement for the retinoblastoma protein family during neuronal determination

6 July 2018

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Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

6 July 2018

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6 July 2018

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Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA

6 July 2018

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MECP2 mutation in male patients with non-specific X-linked mental retardation.

6 July 2018

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MECP2 mutation in a boy with severe neonatal encephalopathy: clinical, neuropathological and molecular findings

21 January 2018

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Novel exon 1 mutations in MECP2 implicate isoform MeCP2_e1 in classical Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049763

Mutations in MECP2 exon 1 in classical Rett patients disrupt MECP2_e1 transcription, but not transcription of MECP2_e2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049763

Differential distribution of the MeCP2 splice variants in the postnatal mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049763

Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049763

Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049763

A segment of the Mecp2 promoter is sufficient to drive expression in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0049763

10.1371/JOURNAL.PONE.0049763

21 January 2018

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DOI

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2 August 2017

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2 August 2017

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