Platelet integrin alphaIIbbeta3-ligand interactions: what can we learn from the structure? (Q34496409)

2 August 2017

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title

Platelet integrin alphaIIbbeta3-ligand interactions: what can we learn from the structure? (English)

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2 August 2017

Kamata T

1

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PubMed ID

11794692

2 August 2017

Takada Y

series ordinal

2

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2 August 2017

1 December 2001

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International Journal of Hematology

2 August 2017

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2 August 2017

74

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2 August 2017

4

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2 August 2017

382-389

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https://scigraph.springernature.com/pub.10.1007/bf02982080

2 August 2017

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cites work

Platelet glycoprotein IIb/IIIa receptors and Glanzmann's thrombasthenia

1 reference

https://api.crossref.org/works/10.1007%2FBF02982080

Lack of integrin alpha-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02982080

Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02982080

Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02982080

Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02982080

Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02982080

Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

21 January 2018

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12 December 2020

Ligand binding to integrin alphaIIbbeta3 is dependent on a MIDAS-like domain in the beta3 subunit

1 reference

12 December 2020

Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

1 reference

12 December 2020

The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit.

1 reference

12 December 2020

Molecular requirements for assembly and function of a minimized human integrin alphaIIbbeta3.

1 reference

12 December 2020

The I domain of integrin LFA-1 interacts with ICAM-1 domain 1 at residue Glu-34 but not Gln-73.

1 reference

12 December 2020

A mutation in the alpha subunit of the platelet integrin alphaIIbbeta3 identifies a novel region important for ligand binding

1 reference

12 December 2020

Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate

1 reference

12 December 2020

Beta propellers: structural rigidity and functional diversity

1 reference

12 December 2020

Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors

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12 December 2020

Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generation of active fragments from either active or inactive GPIIb-IIIa

1 reference

12 December 2020

Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).

1 reference

12 December 2020

Expression and function of calcium binding domain chimeras of the integrins alpha(IIb) and alpha(5)

1 reference

12 December 2020

Binding of glycoprotein IIIa-derived peptide 217-231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complex

1 reference

12 December 2020

Changing Ligand Specificities of αvβ1 and αvβ3 Integrins by Swapping a Short Diverse Sequence of the β Subunit

1 reference

12 December 2020

Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner

1 reference

12 December 2020

Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets

1 reference

12 December 2020

Characterization of Cation-Binding Sequences in the Platelet Integrin GPIIb-IIIa (.alpha.IIb.beta.3) by Terbium Luminescence

1 reference

12 December 2020

Integrins: emerging paradigms of signal transduction

1 reference

12 December 2020

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

12 December 2020

Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

1 reference

12 December 2020

A new model of dual interacting ligand binding sites on integrin alphaIIbbeta3.

1 reference

12 December 2020

Mechanisms initiating platelet thrombus formation

1 reference

12 December 2020

Binding of a fibrinogen mimetic stabilizes integrin alphaIIbbeta3's open conformation

1 reference

12 December 2020

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

1 reference

12 December 2020

Peptides derived from a sequence within beta 3 integrin bind to platelet alpha IIb beta 3 (GPIIb-IIIa) and inhibit ligand binding

1 reference

12 December 2020

Function and interactions of integrins

1 reference

12 December 2020

Mutation of putative divalent cation sites in the alpha 4 subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin

1 reference

12 December 2020

Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide

1 reference

12 December 2020

Molecular Basis of Ligand Recognition by Integrin α5β1

1 reference

12 December 2020

Ca(2+)-binding properties of the platelet glycoprotein IIb ligand-interacting domain

1 reference

12 December 2020

Interaction of integrins alpha v beta 3 and glycoprotein IIb-IIIa with fibrinogen. Differential peptide recognition accounts for distinct binding sites

1 reference

12 December 2020

The integrin alpha IIb-beta 3, platelet glycoprotein IIb-IIIa, can form a functionally active heterodimer complex without the cysteine-rich repeats of the beta 3 subunit.

1 reference

12 December 2020

Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18)

1 reference

12 December 2020

The cation-binding domain from the alpha subunit of integrin alpha5 beta1 is a minimal domain for fibronectin recognition

1 reference

12 December 2020

Adhesion of platelets to surface-bound fibrinogen under flow

1 reference

12 December 2020

Competition for related but nonidentical binding sites on the glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins

1 reference

12 December 2020

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).

1 reference

12 December 2020

Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to "integrin".

1 reference

12 December 2020

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

1 reference

12 December 2020

Old concepts and new developments in the study of platelet aggregation

1 reference

12 December 2020

Ligand binding to integrins

1 reference

12 December 2020

Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association

1 reference

12 December 2020

Integrin LFA-1 alpha subunit contains an ICAM-1 binding site in domains V and VI.

1 reference

12 December 2020

A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1 reference

12 December 2020

Integrin signaling: the platelet paradigm

1 reference

12 December 2020

A discrete sequence in a platelet integrin is involved in ligand recognition

1 reference

12 December 2020

A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3.

1 reference

12 December 2020

Role of endoproteolytic processing in the adhesive and signaling functions of alphavbeta5 integrin

1 reference

12 December 2020

Platelet membrane glycoproteins and their function: an overview

1 reference

12 December 2020

Critical residues for ligand binding in an I domain-like structure of the integrin beta1 subunit.

1 reference

12 December 2020

The platelet membrane glycoprotein IIb-IIIa complex.

1 reference

12 December 2020

Role of fibrinogen alpha and gamma chain sites in platelet aggregation

1 reference

12 December 2020

Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

1 reference

12 December 2020

A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain.

1 reference

12 December 2020

Peptide ligands can bind to distinct sites in integrin alphaIIbbeta3 and elicit different functional responses

1 reference

12 December 2020

A minimized human integrin alpha(5)beta(1) that retains ligand recognition

1 reference

12 December 2020

Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain

1 reference

12 December 2020

Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase

1 reference

12 December 2020

1 reference

12 December 2020

Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis

1 reference

12 December 2020

Isolation and characterization of a chymotryptic fragment of platelet glycoprotein IIb-IIIa retaining Arg-Gly-Asp binding activity

1 reference

12 December 2020

Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy

1 reference

12 December 2020

The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3

1 reference

12 December 2020

A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex

1 reference

12 December 2020

Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).

1 reference

12 December 2020

Ligand and cation binding are dual functions of a discrete segment of the integrin β3 subunit: Cation displacement is involved in ligand binding

1 reference

12 December 2020

Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex

1 reference

12 December 2020

Molecular Basis of Ligand Recognition by Integrin α5β1

1 reference

12 December 2020

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

12 December 2020

Generation of a minimal alpha5beta1 integrin-Fc fragment

1 reference

12 December 2020

Alpha 3 beta 1 adhesion to laminin-5 and invasin: critical and differential role of integrin residues clustered at the boundary between alpha 3 N-terminal repeats 2 and 3.

1 reference

12 December 2020

Platelet collagen receptors

1 reference

12 December 2020

An allosteric Ca2+ binding site on the beta3-integrins that regulates the dissociation rate for RGD ligands

1 reference

12 December 2020

Multiple loop structures critical for ligand binding of the integrin alpha4 subunit in the upper face of the beta-propeller mode 1

1 reference

12 December 2020

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation

1 reference

12 December 2020

The N-terminal region and the mid-region complex of the integrin beta 2 subunit

1 reference

12 December 2020

Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor

1 reference

12 December 2020

Domains in plexins: links to integrins and transcription factors

1 reference

12 December 2020

Peptide-specific antibodies as probes of the topography of the Ca2+-binging motifs in alphaIIbbeta3

1 reference

12 December 2020

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

1 reference

12 December 2020

A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding

1 reference

12 December 2020

Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells.

1 reference

12 December 2020

Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors

1 reference

12 December 2020

Cell adhesion in vascular biology. New insights into integrin-ligand interaction

1 reference

12 December 2020

Long range propagation of conformational changes in integrin alpha IIb beta 3.

1 reference

12 December 2020

Glanzmann thrombasthenia: integrin alpha IIb beta 3 deficiency.

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02982080

1 reference

PubMed ID

11794692

Dimensions Publication ID

2 August 2017

0 references

1 reference

PubMed ID

11794692