Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy. (Q34497376)

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English	Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.	scientific article

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18 January 2020

Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy (English)

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18 January 2020

Streptomyces argillaceus

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Streptomyces plicatus

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Streptomyces tanashiensis

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Streptomyces atroolivaceus

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Streptomyces rochei

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CFCUWKMKBJTWLW-XGHULXNCSA-N

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1 reference

Francesco Bertoni

9

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18 January 2020

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Veronica Albertini

1

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18 January 2020

Aklank Jain

2

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18 January 2020

Sara Vignati

3

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18 January 2020

Sara Napoli

4

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18 January 2020

Andrea Rinaldi

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18 January 2020

Ivo Kwee

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18 January 2020

Mohammad Nur-e-Alam

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18 January 2020

Julia Bergant

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18 January 2020

Giuseppina M Carbone

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18 January 2020

Jürgen Rohr

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18 January 2020

Carlo V Catapano

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29 March 2006

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18 January 2020

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https://academic.oup.com/nar/article-pdf/34/6/1721/7127921/gkl063.pdf

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Nucleic Acids Research

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18 January 2020

34

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18 January 2020

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18 January 2020

1721-1734

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18 January 2020

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Sp transcription factor family and its role in cancer

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7 July 2018

Transcription factor therapeutics: long-shot or lodestone

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7 July 2018

Down-regulation of overexpressed sp1 protein in human fibrosarcoma cell lines inhibits tumor formation.

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A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.

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7 July 2018

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

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7 July 2018

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease

1 reference

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7 July 2018

The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3

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Cholesteryl ester transfer protein promoter single-nucleotide polymorphisms in Sp1-binding sites affect transcription and are associated with high-density lipoprotein cholesterol

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Triplex DNA-mediated downregulation of Ets2 expression results in growth inhibition and apoptosis in human prostate cancer cells

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The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).

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7 July 2018

DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene

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7 July 2018

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs

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7 July 2018

Metabolic engineering for drug discovery and development

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7 July 2018

MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED TESTICULAR NEOPLASMS

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7 July 2018

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7 July 2018

Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target

1 reference

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7 July 2018

Sp1 and Sp3 Are Oxidative Stress-Inducible, Antideath Transcription Factors in Cortical Neurons

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7 July 2018

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis

1 reference

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7 July 2018

Selective inhibition of transcription of the Ets2 gene in prostate cancer cells by a triplex-forming oligonucleotide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1420802

7 July 2018

Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1420802

7 July 2018

Transcription factors as targets for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1420802

7 July 2018

Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells

1 reference

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7 July 2018

Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease

1 reference

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7 July 2018

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1420802

7 July 2018

Interaction of Huntington disease protein with transcriptional activator Sp1

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7 July 2018

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

1 reference

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Significance analysis of microarrays applied to the ionizing radiation response

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Sp1 decoy transfected to carcinoma cells suppresses the expression of vascular endothelial growth factor, transforming growth factor beta1, and tissue factor and also cell growth and invasion activities

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7 July 2018

Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma.

1 reference

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7 July 2018

A tale of three fingers: the family of mammalian Sp/XKLF transcription factors

1 reference

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7 July 2018

Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

1 reference

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1 reference

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7 July 2018

Solution Structure of Mithramycin Dimers Bound to Partially Overlapping Sites on DNA

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7 July 2018

Mithramycin selectively inhibits transcription of G-C containing DNA.

1 reference

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7 July 2018

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7 July 2018

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7 July 2018

Mithramycin selectively inhibits the transcriptional activity of a transfected human c-myc gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1420802

7 July 2018

Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo

1 reference

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7 July 2018

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7 July 2018

Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus

1 reference

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1 reference

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1 reference

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12 December 2020

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1 reference

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1 reference

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12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/16571899

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/16571899

12 December 2020

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/16571899

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1093/NAR/GKL063

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18 January 2020

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18 January 2020

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18 January 2020

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