Interaction of Huntington disease protein with transcriptional activator Sp1 (Q24537687)

2

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Hui Zhou

3

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Suzanne Lam

4

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Manjula Rao

5

0 references

He Li

6

0 references

Xiao-Jiang Li

Molecular and Cellular Biology

7

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language of work or name

English

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publication date

March 2002

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published in

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volume

22

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issue

5

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page(s)

1277-87

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cites work

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity

24 March 2017

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Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice

24 March 2017

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Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

24 March 2017

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Interaction of huntingtin-associated protein with dynactin P150Glued

24 March 2017

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

24 March 2017

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Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter

24 March 2017

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Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

24 March 2017

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Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

24 March 2017

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

24 March 2017

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Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif

7 April 2017

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Pitfall of an internal control plasmid: response of Renilla luciferase (pRL-TK) plasmid to dihydrotestosterone and dexamethasone

7 April 2017

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Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

27 September 2017

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Glutamine repeats and neurodegeneration

27 September 2017

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Three zinc finger nuclear proteins, Sp1, Sp3, and a ZBP-89 homologue, bind to the cyclic adenosine monophosphate-responsive sequence of the bovine adrenodoxin gene and regulate transcription

27 September 2017

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Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.

27 September 2017

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Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

27 September 2017

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Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors

27 September 2017

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Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation

27 September 2017

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The influence of huntingtin protein size on nuclear localization and cellular toxicity.

27 September 2017

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Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

27 September 2017

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Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

27 September 2017

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Glutamine repeats as polar zippers: their possible role in inherited neurodegenerative diseases

27 September 2017

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Sp1-mediated transcriptional activation is repressed by Sp3

27 September 2017

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Transcriptional activation modulated by homopolymeric glutamine and proline stretches

27 September 2017

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

27 September 2017

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Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

30 May 2018

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Regulation of the rat p75 neurotrophin receptor promoter by GC element binding proteins

30 May 2018

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Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter

30 May 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

30 May 2018

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Huntington aggregates may not predict neuronal death in Huntington's disease

29 November 2018

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Nuclear targeting of mutant Huntingtin increases toxicity

29 November 2018

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Amyloid formation by mutant huntingtin: threshold, progressivity and recruitment of normal polyglutamine proteins

29 November 2018

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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

29 November 2018

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

29 November 2018

1 reference

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Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134707

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

29 November 2018

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Nerve growth factor up-regulates the N-methyl-D-aspartate receptor subunit 1 promoter in PC12 cells.

29 November 2018

1 reference

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Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11839795

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular cloning and characterization of the 5' region of the mouse trkA proto-oncogene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11839795

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11839795