CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice (Q34499647)

2 August 2017

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice (English)

1 reference

2 August 2017

0 references

0 references

0 references

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Angela Segler

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sebastian Lange

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jorge de la Rosa

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Juan Cadiñanos

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

George S Vassiliou

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Kristian Unger

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Ignacio Varela

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Allan Bradley

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Julia Weber

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Rupert Öllinger

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Mathias Friedrich

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Ursula Ehmer

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Maxim Barenboim

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Irina Heid

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sebastian Mueller

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Roman Maresch

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Thomas Engleitner

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Nina Gross

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Ulf Geumann

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Beiyuan Fu

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Detian Yuan

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Alexander Strong

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Pentao Liu

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Roland M Schmid

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Günter Schneider

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Fengtang Yang

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Rickmer Braren

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Dieter Saur

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Roland Rad

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Irene Esposito

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Mathias Heikenwälder

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

English

0 references

publication date

27 October 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

45

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

13982-13987

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications

5 June 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Simple and rapid in vivo generation of chromosomal rearrangements using CRISPR/Cas9 technology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Rapid modelling of cooperating genetic events in cancer through somatic genome editing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

CRISPR-Cas9 knockin mice for genome editing and cancer modeling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

CRISPR-mediated direct mutation of cancer genes in the mouse liver

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

CRISPR-Cas systems for editing, regulating and targeting genomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Genome-scale CRISPR-Cas9 knockout screening in human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Genetic screens in human cells using the CRISPR-Cas9 system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

RNA-guided human genome engineering via Cas9

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Multiplex genome engineering using CRISPR/Cas systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

RNA-guided genetic silencing systems in bacteria and archaea

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Exploring the genomes of cancer cells: progress and promise

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Harnessing transposons for cancer gene discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

CRISPR/Cas, the immune system of bacteria and archaea

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4653208

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1512392112

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1512392112

Targetted correction of a mutant HPRT gene in mouse embryonic stem cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1512392112

Exome sequencing of liver fluke-associated cholangiocarcinoma

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26508638

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1512392112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26508638%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

1 reference