Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities (Q34500616)

2 August 2017

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title

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities (English)

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2 August 2017

1

Ines Batinic-Haberle

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2 August 2017

7

Zeljko Vujaskovic

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2 August 2017

Ivan Spasojevic

2

1 reference

2 August 2017

Hubert M Tse

3

1 reference

2 August 2017

Artak Tovmasyan

4

1 reference

2 August 2017

Zrinka Rajic

5

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2 August 2017

Daret K St Clair

6

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2 August 2017

Mark W Dewhirst

8

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2 August 2017

Jon D Piganelli

9

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2 August 2017

16 May 2010

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2 August 2017

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2 August 2017

42

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2 August 2017

1

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2 August 2017

95-113

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https://scigraph.springernature.com/pub.10.1007/s00726-010-0603-6

2 August 2017

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cites work

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High lipophilicity of meta Mn(III) N-alkylpyridylporphyrin-based superoxide dismutase mimics compensates for their lower antioxidant potency and makes them as effective as ortho analogues in protecting superoxide dismutase-deficient Escherichia coli

7 July 2018

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Determination of residual manganese in Mn porphyrin-based superoxide dismutase (SOD) and peroxynitrite reductase mimics

7 July 2018

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Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.

7 July 2018

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Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance

7 July 2018

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Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor

7 July 2018

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Increased manganese superoxide dismutase expression or treatment with manganese porphyrin potentiates dexamethasone-induced apoptosis in lymphoma cells

7 July 2018

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7 July 2018

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7 July 2018

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

7 July 2018

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Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway

7 July 2018

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Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.

7 July 2018

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Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.

7 July 2018

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Chemical biology of peroxynitrite: kinetics, diffusion, and radicals.

7 July 2018

1 reference

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Redox regulation of nuclear post-translational modifications during NF-kappaB activation

7 July 2018

1 reference

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Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy.

7 July 2018

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Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways

7 July 2018

1 reference

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Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes

7 July 2018

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Radical-free biology of oxidative stress

7 July 2018

1 reference

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Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.

7 July 2018

1 reference

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Targeting lipophilic cations to mitochondria.

7 July 2018

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Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection

7 July 2018

1 reference

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HIF-dependent antitumorigenic effect of antioxidants in vivo

7 July 2018

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Only one of a wide assortment of manganese-containing SOD mimicking compounds rescues the slow aerobic growth phenotypes of both Escherichia coli and Saccharomyces cerevisiae strains lacking superoxide dismutase enzymes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress

7 July 2018

1 reference

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Glutathione is recruited into the nucleus in early phases of cell proliferation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Manganese porphyrin reduces renal injury and mitochondrial damage during ischemia/reperfusion.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Reactive oxygen species activate the HIF-1alpha promoter via a functional NFkappaB site

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Catalytic antioxidants to treat amyotropic lateral sclerosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Reactions of Manganese Porphyrins with Peroxynitrite and Carbonate Radical Anion

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

AP-1 in cell proliferation and survival

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Manganese(III) biliverdin IX dimethyl ester: a powerful catalytic scavenger of superoxide employing the Mn(III)/Mn(IV) redox couple

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

The evolution of free radicals and oxidative stress

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Inhibition of NF-kappaB DNA binding by nitric oxide

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Inactivation of metabolic enzymes by photo-treatment with zinc meta N-methylpyridylporphyrin.

7 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Manganous phosphate acts as a superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Manganese porphyrin given at symptom onset markedly extends survival of ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Flavin-dependent antioxidant properties of a new series of meso-N,N'-dialkyl-imidazolium substituted manganese(III) porphyrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Effect of potent redox-modulating manganese porphyrin, MnTM-2-PyP, on the Na(+)/H(+) exchangers NHE-1 and NHE-3 in the diabetic rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Superoxide dismutase, lipid peroxidation, and bell-shaped dose response curves

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Kinetics properties of Cu,Zn-superoxide dismutase as a function of metal content

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Spatial redox regulation of a critical cysteine residue of NF-kappa B in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Electrostatic contribution in the catalysis of O2*- dismutation by superoxide dismutase mimics. MnIIITE-2-PyP5+ versus MnIIIBr8T-2-PyP+.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Neuroprotection against staurosporine by metalloporphyrins independent of antioxidant capability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

A mechanism-based antioxidant approach for the reduction of skin carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00726-010-0603-6

New PEG-ylated Mn(III) porphyrins approaching catalytic activity of SOD enzyme

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

An alternative Ca2+-dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3022969

Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants

27 October 2018

1 reference

12 December 2020

Pulse radiolytic investigations of superoxide catalyzed disproportionation. Mechanism for bovine superoxide dismutase

1 reference

12 December 2020

Kinetic properties of Cu,Zn-superoxide dismutase as a function of metal content--order restored

1 reference

12 December 2020

New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system

1 reference

12 December 2020

APE1/Ref-1: versatility in progress

1 reference

12 December 2020

Response of human islets to isolation stress and the effect of antioxidant treatment

1 reference

12 December 2020

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo

1 reference

12 December 2020

The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium-2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic

1 reference

12 December 2020

Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages

1 reference

12 December 2020

The scavenging of superoxide radical by manganous complexes: In vitro

1 reference

12 December 2020

Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase

1 reference

12 December 2020

Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite

1 reference

12 December 2020

Chemical Properties of Water-soluble Porphyrins 3. The Reaction of Superoxide Radicals with Some Metalloporphyrins

1 reference

12 December 2020

Nitrosylation of manganese(II) tetrakis(N-ethylpyridinium-2-yl)porphyrin: a simple and sensitive spectrophotometric assay for nitric oxide

1 reference

12 December 2020

10.1007/S00726-010-0603-6

Identifiers

DOI

1 reference

2 August 2017

1 reference

2 August 2017

1 reference