Recent insights into the mechanism of glucocorticosteroid-induced apoptosis (Q34502160)

2 August 2017

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title

Recent insights into the mechanism of glucocorticosteroid-induced apoptosis (English)

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2 August 2017

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Distelhorst CW

1

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2 August 2017

1 January 2002

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Cell Death & Differentiation

2 August 2017

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2 August 2017

9

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2 August 2017

1

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2 August 2017

6-19

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400969

2 August 2017

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cites work

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

AP-1 function and regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Relationship between apoptosis and the cell cycle in lymphocytes: roles of protein kinase C, tyrosine phosphorylation, and AP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Nuclear factor of activated T cells (NFAT) is a possible target for dexamethasone in thymocyte apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The many roles of c-Myc in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Glucocorticoid-induced apoptosis and regulation of NF-kappaB activity in human leukemic T cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

DNA binding of the glucocorticoid receptor is not essential for survival

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The wst gene regulates multiple forms of thymocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Transcription factor interactions: selectors of positive or negative regulation from a single DNA element.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Proteolysis, proteasomes and antigen presentation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The ubiquitin-proteasome proteolytic pathway

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Activation of polyubiquitin gene expression during developmentally programmed cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Changes in the structure and function of the multicatalytic proteinase (proteasome) during programmed cell death in the intersegmental muscles of the hawkmoth, Manduca sexta

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Developmental changes of the 26 S proteasome in abdominal intersegmental muscles of Manduca sexta during programmed cell death.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Proteasomes play an essential role in thymocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Proteasome activities decrease during dexamethasone-induced apoptosis of thymocytes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Proteasome activation as a critical event of thymocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

c-Fos degradation by the proteasome. An early, Bcl-2-regulated step in apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Biochemical and kinetic characterization of the glucocorticoid-induced apoptosis of immature CD4+CD8+ thymocytes.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Inhibition of Proteasome Function Prevents Thymocyte Apoptosis: Involvement of Ornithine Decarboxylase

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

A link between cell cycle and cell death: Bax and Bcl-2 modulate Cdk2 activation during thymocyte apoptosis.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Apoptotic pathways: paper wraps stone blunts scissors

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Steroid and nuclear receptors. Villefranche-sur-Mer, France, May 25-27, 1999.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Interleukin-15 protects from lethal apoptosis in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Mechanisms in interleukin-2 protection against glucocorticoid-induced apoptosis: regulation of AP-1 and glucocorticoid receptor transcriptional activities

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Cytokine rescue from glucocorticoid induced apoptosis in T cells is mediated through inhibition of IkappaBalpha

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Glucocorticoid-mediated repression of NFkappaB activity in endothelial cells does not involve induction of IkappaBalpha synthesis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Ras enhances Myc protein stability.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Interaction of the ligand-activated glucocorticoid receptor with the 14-3-3 eta protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Glucocorticoid receptor interaction with 14-3-3 and Raf-1, a proposed mechanism for cross-talk of two signal transduction pathways

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Apoptosis induction by the glucocorticoid hormone dexamethasone and the calcium-ATPase inhibitor thapsigargin involves Bc1-2 regulated caspase activation.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Distinct alterations in mitochondrial mass and function characterize different models of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Mitochondrial control of cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Commitment to cell death measured by loss of clonogenicity is separable from the appearance of apoptotic markers

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Biochemical pathways of caspase activation during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Identification of a differential display product associated with apoptosis in chicken thymocytes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Bad can act as a key regulator of T cell apoptosis and T cell development.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Intracellular K+ suppresses the activation of apoptosis in lymphocytes

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The involvement of an ATP-gated ion channel, P(2X1), in thymocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

P2x purinoceptor is not important in thymocyte apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Volume regulation and ion transport during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

A primary role for K+ and Na+ efflux in the activation of apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Regulation of ceramide production and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Apoptosis and sphingomyelin hydrolysis. The flip side

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Characterization of Apt- cell lines exhibiting cross-resistance to glucocorticoid- and Fas-mediated apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Characterization of mice deficient in interleukin-1 beta converting enzyme

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Prolactin blocks glucocorticoid induced cell death by inhibiting the disruption of the mitochondrial membrane.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Assessment of caspase activities in intact apoptotic thymocytes using cell-permeable fluorogenic caspase substrates

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Mitochondrial perturbations define lymphocytes undergoing apoptotic depletion in vivo

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Cytochrome c-dependent and -independent induction of apoptosis in multiple myeloma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Bcl-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

BCL-2 expression in childhood leukemia versus spontaneous apoptosis, drug induced apoptosis, and in vitro drug resistance

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4400969

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4400969

1 reference

2 August 2017

1 reference

PubMed ID

11803370