Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances (Q34503551)

2 August 2017

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title

Further insights into the neurobiology of melanin-concentrating hormone in energy and mood balances (English)

1 reference

2 August 2017

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Guillaume J Hervieu

1

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2 August 2017

language of work or name

English

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publication date

1 April 2006

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Expert Opinion on Therapeutic Targets

2 August 2017

published in

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2 August 2017

volume

10

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2 August 2017

issue

2

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2 August 2017

page(s)

211-229

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Melanin-concentration hormone updated functional considerations

2 August 2017

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The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance.

21 January 2018

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Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size

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Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity

21 January 2018

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Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics

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Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

21 January 2018

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Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice.

21 January 2018

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Corticotropin-releasing factor, norepinephrine, and stress

21 January 2018

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Neurobiology of depression

21 January 2018

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Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists

21 January 2018

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Rats lighten up with MCH antagonist

21 January 2018

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Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As?

21 January 2018

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

21 January 2018

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Intracerebroventricular melanin-concentrating hormone stimulates food intake in sheep

21 January 2018

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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

21 January 2018

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The temporal organization of ingestive behaviour and its interaction with regulation of energy balance

21 January 2018

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The role of previous exposure in the appetitive and consummatory effects of orexigenic neuropeptides

21 January 2018

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Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance

21 January 2018

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KO's and organisation of peptidergic feeding behavior mechanisms

21 January 2018

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Hypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in rats

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Neuropeptides, including neuropeptide Y and melanocortins, mediate lipolysis in murine adipocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Circulating melanin-concentrating hormone, agouti-related protein, and alpha-melanocyte-stimulating hormone levels in relation to body composition: alterations in response to food deprivation and recombinant human leptin administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Expression of melanin-concentrating hormone receptors in insulin-producing cells: MCH stimulates insulin release in RINm5F and CRI-G1 cell-lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone regulates leptin synthesis and secretion in rat adipocytes

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Hypothalamic pro-opiomelanocortin mRNA is reduced by fasting and [corrected] in ob/ob and db/db mice, but is stimulated by leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Effects of leptin on melanin-concentrating hormone expression in the brain of lean and obese Lep(ob)/Lep(ob) mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Characterization of orexins (hypocretins) and melanin-concentrating hormone in genetically obese mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Central and peripheral dysregulation of melanin-concentrating hormone in obese Zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Increases in melanin-concentrating hormone and MCH receptor levels in the hypothalamus of dietary-obese rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone is a potent anorectic peptide regulated by food-deprivation and glucopenia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Increased hypothalamic melanin concentrating hormone gene expression during energy restriction involves a melanocortin-independent, estrogen-sensitive mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Novel hypothalamic and preoptic sites of prepro-melanin-concentrating hormone messenger ribonucleic Acid and Peptide expression in lactating rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Central and peripheral immunoreactivity of melanin-concentrating hormone in hypothalamic obese and lactating rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Structure-activity relationship studies of melanin-concentrating hormone (MCH)-related peptide ligands at SLC-1, the human MCH receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone receptor is a target of leptin action in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexia.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone receptor mutations and human obesity: functional analysis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization

21 January 2018

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Melanotropic peptides in the mammalian brain: the melanin-concentrating hormone

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The lateral hypothalamic area revisited: ingestive behavior

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

From lesions to leptin: hypothalamic control of food intake and body weight.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Hypothalamic neuronal networks and feeding-related peptides involved in the regulation of feeding

21 January 2018

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The hypothalamus and obesity

21 January 2018

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The distribution of the mRNA and protein products of the melanin-concentrating hormone (MCH) receptor gene, slc-1, in the central nervous system of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

21 January 2018

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The need to feed: homeostatic and hedonic control of eating

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Comparison of hypocretin/orexin and melanin-concentrating hormone neurons and axonal projections in the embryonic and postnatal rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

21 January 2018

Anabolic neuropeptides

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Neuropeptides and obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Effects of neuropeptides and leptin on nutrient partitioning: dysregulations in obesity

21 January 2018

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Neurons Synthesizing Melanin-Concentrating Hormone Identified by Selective Reporter Gene Expression After Transfection In Vitro: Transmitter Responses

21 January 2018

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Identification of hypothalamic nuclei involved in the orexigenic effect of melanin-concentrating hormone

21 January 2018

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Hypothalamic neuropeptide mechanisms for regulating energy balance: from rodent models to human obesity

21 January 2018

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Anti-obesity drugs: a critical review of current therapies and future opportunities

21 January 2018

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The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Plasma membrane and vesicular glutamate transporter mRNAs/proteins in hypothalamic neurons that regulate body weight.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Chemical coding of GABA(B) receptor-immunoreactive neurones in hypothalamic regions regulating body weight

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Cellular localization of GABA receptor alpha subunit immunoreactivity in the rat hypothalamus: relationship with neurones containing orexigenic or anorexigenic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Estradiol-induced anorexia is independent of leptin and melanin-concentrating hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Origin of cocaine- and amphetamine-regulated transcript (CART)-immunoreactive innervation of the hypothalamic paraventricular nucleus

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Characterization of subpopulations of neurons producing melanin-concentrating hormone in the rat ventral diencephalon.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Expression of hypothalamic neuropeptides after acute TCDD treatment and distribution of Ah receptor repressor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Importance of melanin-concentrating hormone receptor for the acute effects of ghrelin

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Effect of direct injection of melanin-concentrating hormone into the paraventricular nucleus: further evidence for a stimulatory role in the adrenal axis via SLC-1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Differential effects of adrenalectomy on melanin-concentrating hormone and orexin A.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Prenatal glucocorticoids and long-term programming

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Metabolic imprinting on genetically predisposed neural circuits perpetuates obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Neuroscience. The fat-brain axis enters a new dimension

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Altered responses to orexigenic (AGRP, MCH) and anorexigenic (alpha-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Inactivation of the GR in the nervous system affects energy accumulation

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Hypercortisolism and obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Behavioral effects of alpha-MSH and MCH after central administration in the female rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Anxiogenesis induced by nitric oxide synthase inhibition and anxiolytic effect of melanin-concentrating hormone (MCH) in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Early experience as a determinant of adult behavioural responses to reward: the effects of repeated maternal separation in the rat

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Melanin-concentrating hormone receptor: an orphan receptor fits the key.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Enhancement of antidepressant potency by a potentiator of AMPA receptors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Neuropeptides: opportunities for drug discovery

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Orphan G protein-coupled receptors and obesity

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Current and investigational antiobesity agents and obesity therapeutic treatment targets

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The hypothalamic-pituitary-adrenal axis in the neuroendocrine regulation of food intake and obesity: the role of corticotropin releasing hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Trends in the development of new antidepressants. Is there a light at the end of the tunnel?

21 January 2018

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Future antidepressants: what is in the pipeline and what is missing?

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Serotonin and the neuroendocrine regulation of the hypothalamic--pituitary-adrenal axis in health and disease

21 January 2018

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Lateral hypothalamic neuropeptides in reward and drug addiction

21 January 2018

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Augmentation of drug reward by chronic food restriction: behavioral evidence and underlying mechanisms.

21 January 2018

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Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript peptide

21 January 2018

1 reference

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Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of dopamine in tuberoinfundibular neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin

21 January 2018

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Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.

21 January 2018

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Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with G(s)-coupled pathways

21 January 2018

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Two important systems in energy homeostasis: melanocortins and melanin-concentrating hormone

21 January 2018

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Melanocortins and opiate addiction

21 January 2018

1 reference

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Osteoporosis in MCHR1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Increased susceptibility to LTP generation and changes in NMDA-NR1 and -NR2B subunits mRNA expression in rat hippocampus after MCH administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

The physiology of learning and memory: role of peptides and stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Complex effects of stromal cell-derived factor-1 alpha on melanin-concentrating hormone neuron excitability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

A virtual screening approach to finding novel and potent antagonists at the melanin-concentrating hormone 1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Synthesis and evaluation of urea-based indazoles as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

A screening library for peptide activated G-protein coupled receptors. 1. The test set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Discovery of melanin-concentrating hormone receptor R1 antagonists using high-throughput synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.10.2.211

Prevalence and trends in overweight among US children and adolescents, 1999-2000

21 January 2018

1 reference

28 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1001/JAMA.288.14.1728

Identifiers

DOI

10.1517/14728222.10.2.211

1 reference

2 August 2017

1 reference