PP2A inhibition overcomes acquired resistance to HER2 targeted therapy (Q34504365)

2 August 2017

PP2A inhibition overcomes acquired resistance to HER2 targeted therapy (English)

1 reference

2 August 2017

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Martina Sj McDermott

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Brigid C Browne

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Neil T Conlon

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Neil A O'Brien

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Dennis J Slamon

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Michael Henry

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Paula Meleady

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Martin Clynes

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

John Crown

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Norma O'Donovan

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

publication date

24 June 2014

1 reference

2 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

9 June 2020

ImageQuant

object named as

ImageQuant

2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4230643/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

exact match

https://scigraph.springernature.com/pub.10.1186/1476-4598-13-157

0 references

cites work

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Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase

7 July 2018

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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis

7 July 2018

1 reference

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PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells

7 July 2018

1 reference

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Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial

7 July 2018

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Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

7 July 2018

1 reference

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Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

7 July 2018

1 reference

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β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib

7 July 2018

1 reference

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Evaluation of the association of PIK3CA mutations and PTEN loss with efficacy of trastuzumab therapy in metastatic breast cancer.

7 July 2018

1 reference

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Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition.

7 July 2018

1 reference

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Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy

7 July 2018

1 reference

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2D-DIGE analysis of phospho-enriched fractions from dasatinib-treated melanoma cell lines

7 July 2018

1 reference

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A synthetic cantharidin analog for the enhancement of doxorubicin suppression of stem cell-derived aggressive sarcoma

7 July 2018

1 reference

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Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells

7 July 2018

1 reference

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Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinib

7 July 2018

1 reference

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X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor

7 July 2018

1 reference

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Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase inhibitors in HER-2 positive breast cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma

7 July 2018

1 reference

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Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.

7 July 2018

1 reference

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PANTHER pathway: an ontology-based pathway database coupled with data analysis tools

7 July 2018

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Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

7 July 2018

1 reference

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Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

7 July 2018

1 reference

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Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation

7 July 2018

1 reference

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Multiple pathways regulated by the tumor suppressor PP2A in transformation

7 July 2018

1 reference

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Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

7 July 2018

1 reference

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Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

7 July 2018

1 reference

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

7 July 2018

1 reference

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Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase

7 July 2018

1 reference

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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

7 July 2018

1 reference

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Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells

7 July 2018

1 reference

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Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

7 July 2018

1 reference

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Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas

7 July 2018

1 reference

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ERBB receptors and cancer: the complexity of targeted inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Regulation of peptide-chain elongation in mammalian cells

7 July 2018

1 reference

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Fostriecin: chemistry and biology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Functional properties of phosphorylated elongation factor 2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Humanization of an anti-p185HER2 antibody for human cancer therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-157

Durable complete response following chemotherapy and trastuzumab for metastatic HER2-positive breast cancer.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1186%2F1476-4598-13-157

Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function

21 January 2018

1 reference

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https://api.crossref.org/works/10.1186%2F1476-4598-13-157

Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4230643

Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24958351

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-13-157

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24958351%20AND%20SRC:MED&resulttype=core&format=json