Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways (Q44127144)

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English	Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways	scientific article

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scholarly article

1 reference

Europe PubMed Central

30 November 2017

Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways (English)

1 reference

Europe PubMed Central

30 November 2017

author name string

Wenle Xia

1

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Europe PubMed Central

30 November 2017

Robert J Mullin

2

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Europe PubMed Central

30 November 2017

Barry R Keith

3

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Europe PubMed Central

30 November 2017

Lei-Hua Liu

4

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Europe PubMed Central

30 November 2017

Hong Ma

5

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Europe PubMed Central

30 November 2017

David W Rusnak

6

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Europe PubMed Central

30 November 2017

Gary Owens

7

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Europe PubMed Central

30 November 2017

Krystal J Alligood

8

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Europe PubMed Central

30 November 2017

Neil L Spector

9

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Europe PubMed Central

30 November 2017

language of work or name

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publication date

1 September 2002

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Europe PubMed Central

30 November 2017

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Europe PubMed Central

30 November 2017

21

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30 November 2017

41

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30 November 2017

6255-6263

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30 November 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1205794

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Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Take your partners, please--signal diversification by the erbB family of receptor tyrosine kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

New model of ErbB-2 over-expression in human mammary luminal epithelial cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Aberrant regulation of transforming growth factor-alpha during the establishment of growth arrest and quiescence of growth factor independent cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Autocrine transforming growth factor alpha provides a growth advantage to malignant cells by facilitating re-entry into the cell cycle from suboptimal growth states.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

An alternative to SH2 domains for binding tyrosine-phosphorylated proteins

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Tyrosine kinase inhibition: an approach to drug development

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Involvement of pp60c-src with two major signaling pathways in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Specificity within the EGF family/ErbB receptor family signaling network

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Epidermal growth factor-related peptides and their receptors in human malignancies

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Strain-dependent epithelial defects in mice lacking the EGF receptor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

The pathway to signal achievement

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

21 January 2018

Serum predominantly activates MAPK and akt kinases in EGFR- and ErbB2-over-expressing cells, respectively

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

7 January 2021

based on heuristic

inferred from DOI database lookup

Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205794

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1205794

1 reference

Europe PubMed Central

30 November 2017

1 reference

Europe PubMed Central

30 November 2017

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