MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation. (Q34507966)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20593220%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation (English)

1 reference

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6 February 2020

1 reference

1 reference

5

1 reference

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6 February 2020

Martin J van den Bent

6

1 reference

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6 February 2020

8

Winand N M Dinjens

1 reference

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6 February 2020

author name string

Floris H Groenendijk

1

1 reference

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6 February 2020

Walter Taal

2

1 reference

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6 February 2020

Hendrikus J Dubbink

3

1 reference

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6 February 2020

Cathleen R Haarloo

4

1 reference

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6 February 2020

Johan M Kros

7

1 reference

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6 February 2020

publication date

1 July 2010

1 reference

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Journal of Neuro-Oncology

6 February 2020

published in

1 reference

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6 February 2020

volume

101

1 reference

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6 February 2020

issue

3

1 reference

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6 February 2020

page(s)

405-417

1 reference

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O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications

6 February 2020

cites work

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MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas

7 July 2018

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The 2007 WHO classification of tumours of the central nervous system

7 July 2018

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Genetic pathways to primary and secondary glioblastoma

7 July 2018

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7 July 2018

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Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas

7 July 2018

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7 July 2018

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7 July 2018

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

7 July 2018

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Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer

7 July 2018

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Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course.

7 July 2018

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7 July 2018

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Determination of the molecular relationship between multiple tumors within one patient is of clinical importance

7 July 2018

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Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones

7 July 2018

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

7 July 2018

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Incidence and timing of p53 mutations during astrocytoma progression in patients with multiple biopsies

7 July 2018

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Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression.

7 July 2018

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Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities.

7 July 2018

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Genetic pathways to glioblastoma: a population-based study

28 July 2018

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Prognostic impact of TP53 mutation status for adult patients with supratentorial World Health Organization Grade II astrocytoma or oligoastrocytoma: a long-term analysis.

21 January 2018

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Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas

21 January 2018

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Aberrant hypermethylation of p14ARF and O6-methylguanine-DNA methyltransferase genes in astrocytoma progression

21 January 2018

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Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression

21 January 2018

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CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

21 January 2018

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MGMT methylation: a marker of response to temozolomide in low-grade gliomas

21 January 2018

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Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

21 January 2018

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Hypermethylation of the DNA repair gene MGMT: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors

21 January 2018

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O6-methylguanine-DNA methyltransferase methylation and TP53 mutation in malignant astrocytomas and their relationships with clinical course

21 January 2018

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Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

21 January 2018

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High incidence of MGMT promoter methylation in primary glioblastomas without correlation with TP53 gene mutations

21 January 2018

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Promoter Hypermethylation of the DNA Repair Gene O6‐Methylguanine‐DNA Methyltransferase is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas

21 January 2018

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Prognostic impact of TP53 mutations and P53 protein overexpression in supratentorial WHO grade II astrocytomas and oligoastrocytomas.

27 October 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis

27 October 2018

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

27 October 2018

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DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma

27 October 2018

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TP53 codon 72 polymorphism, p53 expression, and 1p/19q status in oligodendroglial tumors

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20593220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Methylation of multiple genes as diagnostic and therapeutic markers in primary head and neck squamous cell carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20593220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20593220

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11060-010-0274-X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20593220%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20593220%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

20593220

1 reference