The TGF-beta--Smad network: introducing bioinformatic tools (Q34511224)

2 August 2017

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title

The TGF-beta--Smad network: introducing bioinformatic tools (English)

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2 August 2017

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Dorothee U Kloos

1

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PubMed ID

11818142

2 August 2017

Claudia Choi

series ordinal

2

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PubMed ID

11818142

2 August 2017

Edgar Wingender

series ordinal

3

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2 August 2017

1 February 2002

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2 August 2017

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2 August 2017

18

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2 August 2017

2

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2 August 2017

96-103

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Nomenclature: vertebrate mediators of TGFbeta family signals.

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

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https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Signal transduction by bone morphogenetic proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Structural basis of Smad2 recognition by the Smad anchor for receptor activation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Formation of a stable heterodimer between Smad2 and Smad4

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https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Characterization of functional domains within Smad4/DPC4

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https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Crystal structure of a transcriptionally active Smad4 fragment

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Characterization of a bone morphogenetic protein-responsive Smad-binding element

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Interaction of Smad complexes with tripartite DNA-binding sites

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https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

A transcriptional partner for MAD proteins in TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

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https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Mad-related genes in the human

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Specificity, diversity, and regulation in TGF-beta superfamily signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Importin beta mediates nuclear translocation of Smad 3

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad7 and Smad6 differentially modulate transforming growth factor beta -induced inhibition of embryonic lung morphogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Calmodulin differentially modulates Smad1 and Smad2 signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Regulation of Smad signaling by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

The TRANSFAC system on gene expression regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Transcription regulatory region analysis using signal detection and fuzzy clustering

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

COMPEL: a database on composite regulatory elements providing combinatorial transcriptional regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Recognition of NFATp/AP-1 composite elements within genes induced upon the activation of immune cells

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

The TRANSPATH signal transduction database: a knowledge base on signal transduction networks

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

DIP: The Database of Interacting Proteins: 2001 update

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

BIND--The Biomolecular Interaction Network Database

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

The modularity of biological regulatory networks.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity.

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0168-9525%2802%2902556-8

7 January 2021

10.1016/S0168-9525(02)02556-8

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11818142