Limited brain access for leptin in obesity (Q34514768)

2 August 2017

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title

Limited brain access for leptin in obesity (English)

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2 August 2017

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Couce ME

1

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2 August 2017

Green D

2

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2 August 2017

Brunetto A

3

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2 August 2017

Achim C

4

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2 August 2017

Lloyd RV

5

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2 August 2017

Burguera B

6

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2 August 2017

publication date

1 January 2001

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2 August 2017

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2 August 2017

volume

4

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2 August 2017

issue

1-2

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2 August 2017

page(s)

101-110

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CSF leptin levels after exogenous administration of recombinant methionyl human leptin

2 August 2017

cites work

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12 December 2020

Impaired transport of leptin across the blood-brain barrier in obesity

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12 December 2020

Cloning and characterization of novel CIS family genes

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12 December 2020

Persistence of blood-to-brain transport of leptin in obese leptin-deficient and leptin receptor-deficient mice

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A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors

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Localization of leptin receptor in the human brain

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Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

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Positional cloning of the mouse obese gene and its human homologue

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Appetite and the regulation of body composition

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Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice

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Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

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The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter

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12 December 2020

Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women

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12 December 2020

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

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12 December 2020

Leptin reduces ovariectomy-induced bone loss in rats

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12 December 2020

Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling

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12 December 2020

Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin,

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12 December 2020

Current estimates of the economic cost of obesity in the United States

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12 December 2020

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

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12 December 2020

Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation

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12 December 2020

Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans

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12 December 2020

Identification of SOCS-3 as a potential mediator of central leptin resistance

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12 December 2020

A new protein containing an SH2 domain that inhibits JAK kinases

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12 December 2020

Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance

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A family of cytokine-inducible inhibitors of signalling

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12 December 2020

A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the rat.

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12 December 2020

Leptin: the tale of an obesity gene

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12 December 2020

Expression of leptin receptor isoforms in rat brain microvessels

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12 December 2020

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

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12 December 2020

Signals that regulate food intake and energy homeostasis

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12 December 2020

Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion

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Annual Deaths Attributable to Obesity in the United States

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12 December 2020

Leptin enters the brain by a saturable system independent of insulin

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12 December 2020

Genetic and environmental contributions to obesity

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12 December 2020

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

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12 December 2020

Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization

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12 December 2020

Leptin is a potent stimulator of bone growth in ob/ob mice

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12 December 2020

Leptin transport at the blood--cerebrospinal fluid barrier using the perfused sheep choroid plexus model.

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12 December 2020

Is brain uptake of leptin in vivo saturable and reduced by fasting?

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12 December 2020

Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia

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12 December 2020

The transport of sugars across the perfused choroid plexus of the sheep.

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12 December 2020

Weekly subcutaneous pegylated recombinant native human leptin (PEG-OB) administration in obese men.

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12 December 2020

Fate of leptin after intracerebroventricular injection into the mouse brain

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12 December 2020

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

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12 December 2020

Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women.

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12 December 2020

Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice

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12 December 2020

Central administration of leptin inhibits food intake and activates the sympathetic nervous system in rhesus macaques

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12 December 2020

Abnormal splicing of the leptin receptor in diabetic mice

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12 December 2020

Role of set-point theory in regulation of body weight.

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12 December 2020

Leptin receptor and neuropeptide Y gene expression in the sheep brain

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12 December 2020

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

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12 December 2020

Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones, and pubertal stage.

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12 December 2020

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels

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12 December 2020

Obesity in the new millennium

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12 December 2020

Distributions of leptin receptor mRNA isoforms in the rat brain

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12 December 2020

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

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12 December 2020

Neuroendocrine regulation and actions of leptin

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12 December 2020

Overweight, obesity, and health risk

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12 December 2020

Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

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12 December 2020

Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats

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12 December 2020

Leptin and the regulation of body weight in mammals

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12 December 2020

Expression and localization of the leptin receptor in endocrine and neuroendocrine tissues of the rat.

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12 December 2020

Subcellular localization of leptin in non-tumorous and adenomatous human pituitaries: an immuno-ultrastructural study

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12 December 2020

Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

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12 December 2020

Obesity and the hypothalamus: novel peptides for new pathways

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12 December 2020

The long form of the leptin receptor (OB-Rb) is widely expressed in the human brain

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12 December 2020

Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

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12 December 2020

Changes in Energy Expenditure Resulting from Altered Body Weight

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12 December 2020

Effects of weight and body mass index on bone mineral density in men and women: the Framingham study.

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12 December 2020

Identification and expression cloning of a leptin receptor, OB-R

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12 December 2020

Penetration of neurotrophins and cytokines across the blood-brain/blood-spinal cord barrier

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12 December 2020

Seminars in medicine of the Beth Israel Deaconess Medical Center. Neuroendocrine responses to starvation and weight loss

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12 December 2020

Overview: neurobiology of OB protein (leptin).

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12 December 2020

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

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12 December 2020

Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice

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12 December 2020

Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial

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12 December 2020

OB protein binds specifically to the choroid plexus of mice and rats

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12 December 2020

Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks

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12 December 2020

Reflections on STAT3, STAT5, and STAT6 as fat STATs

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12 December 2020

A phase I study including pharmacokinetics of polyethylene glycol conjugated interleukin-2.

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12 December 2020

Increased obese mRNA expression in omental fat cells from massively obese humans

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12 December 2020

Identifiers

DOI

10.1023/A:1012951214106

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Dimensions Publication ID

2 August 2017

1035407017

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