Circuitry of nuclear factor kappaB signaling (Q34514908)

2 August 2017

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title

Circuitry of nuclear factor kappaB signaling (English)

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2 August 2017

2

David Baltimore

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2 August 2017

Alexander Hoffmann

1

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2 August 2017

publication date

1 April 2006

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2 August 2017

published in

Immunological Reviews

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2 August 2017

volume

210

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2 August 2017

page(s)

171-186

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Multiple nuclear factors interact with the immunoglobulin enhancer sequences

2 August 2017

cites work

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Two pathways to NF-kappaB.

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NF-kappaB RelB forms an intertwined homodimer

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The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription

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Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export

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Distinct roles of IkappaB proteins in regulating constitutive NF-kappaB activity.

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Oscillations in NF-kappaB signaling control the dynamics of gene expression

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BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

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Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism

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Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

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NF-kappaB signals induce the expression of c-FLIP.

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Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation

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NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

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Novel NEMO/IkappaB kinase and NF-kappa B target genes at the pre-B to immature B cell transition

21 January 2018

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IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

21 January 2018

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A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta-cells

21 January 2018

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Identification of NF-kappaB-dependent gene networks in respiratory syncytial virus-infected cells

21 January 2018

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Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling.

21 January 2018

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Use of an array technology for profiling and comparing transcription factors activated by TNFalpha and PMA in HeLa cells

21 January 2018

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Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways

21 January 2018

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Distribution of NF-kappaB-binding sites across human chromosome 22

21 January 2018

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A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway

21 January 2018

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Towards a proteome-scale map of the human protein–protein interaction network

21 January 2018

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Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts

21 January 2018

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Control of lymphocyte development by nuclear factor-kappaB.

21 January 2018

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The role of Rel/NF-kappaB transcription factors in B lymphocyte survival

21 January 2018

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The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells

21 January 2018

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Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

21 January 2018

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Gene expression profiling of diffuse large B-cell lymphoma

21 January 2018

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Differential requirement for Rel/nuclear factor kappa B family members in natural killer T cell development

21 January 2018

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Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation

21 January 2018

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Expression of relB is required for the development of thymic medulla and dendritic cells

21 January 2018

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RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

21 January 2018

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Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs

21 January 2018

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Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway

21 January 2018

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Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

21 January 2018

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Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

21 January 2018

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Limiting inflammatory responses during activation of innate immunity

21 January 2018

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Mathematical model of NF-kappaB regulatory module

21 January 2018

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Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Comment on "Oscillations in NF-kappaB signaling control the dynamics of gene expression".

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Stimulus specificity of gene expression programs determined by temporal control of IKK activity

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Achieving stability of lipopolysaccharide-induced NF-kappaB activation

21 January 2018

1 reference

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Transient and selective NF-kappa B p65 serine 536 phosphorylation induced by T cell costimulation is mediated by I kappa B kinase beta and controls the kinetics of p65 nuclear import

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

NF-kappaB RelA phosphorylation regulates RelA acetylation

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Transcriptional activation by NF-kappaB requires multiple coactivators

21 January 2018

1 reference

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter

21 January 2018

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Deciphering the transcriptional histone acetylation code for a human gene

21 January 2018

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Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock

21 January 2018

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.

21 January 2018

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The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Genetic analysis of NF- B/Rel transcription factors defines functional specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Selective requirement for c-Rel during IL-12 P40 gene induction in macrophages

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation.

21 January 2018

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Allosteric effects of DNA on transcriptional regulators

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2006.00375.X

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

21 January 2018

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The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms

21 January 2018

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

I kappa B: a specific inhibitor of the NF-kappa B transcription factor

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

c-Rel is required for chromatin remodeling across the IL-2 gene promoter

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Phorbol-ester-induced activation of the NF-kappa B transcription factor involves dissociation of an apparently cytoplasmic NF-kappa B/inhibitor complex

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

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11 October 2022

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A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Human endothelial cell response to gram-negative lipopolysaccharide assessed with cDNA microarrays

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Effect of interleukin-1β and tumor necrosis factor-α on gene expression in human endothelial cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1111/J.0105-2896.2006.00375.X

Identifiers

DOI

10.1111/J.0105-2896.2006.00375.X

1 reference

2 August 2017

1 reference