A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A. (Q34522635)

2 August 2017

A small molecule directly inhibits the p53 transactivation domain from binding to replication protein A. (English)

1 reference

2 August 2017

6

Gregory G Oakley

1 reference

2 August 2017

Jason G Glanzer

1

1 reference

2 August 2017

Katie A Carnes

2

1 reference

2 August 2017

Patricia Soto

3

1 reference

2 August 2017

Shengqin Liu

4

1 reference

2 August 2017

Lawrence J Parkhurst

5

1 reference

2 August 2017

language of work or name

English

0 references

publication date

24 December 2012

1 reference

2 August 2017

Nucleic Acids Research

1 reference

2 August 2017

41

1 reference

2 August 2017

3

1 reference

2 August 2017

2047-2059

1 reference

Creative Commons Attribution-NonCommercial 3.0 Unported

2 August 2017

start time

12 May 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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7 July 2018

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Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering

7 July 2018

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SSB protein diffusion on single-stranded DNA stimulates RecA filament formation.

7 July 2018

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Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1.

7 July 2018

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7 July 2018

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Reaction of abietic acid with maleic anhydride and fumaric acid and attempts to find the fundamental component of fortified rosin.

7 July 2018

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Dysfunctional homologous recombination mediates genomic instability and progression in myeloma

7 July 2018

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The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling

7 July 2018

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JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

7 July 2018

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Cellular functions of human RPA1. Multiple roles of domains in replication, repair, and checkpoints

7 July 2018

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The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.

7 July 2018

1 reference

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Function of a conserved checkpoint recruitment domain in ATRIP proteins

7 July 2018

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Canonical sampling through velocity rescaling

7 July 2018

1 reference

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A dynamic model for replication protein A (RPA) function in DNA processing pathways

7 July 2018

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p53 transcriptional activation domain: a molecular chameleon?

7 July 2018

1 reference

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Conformational polymorphism of the PrP106-126 peptide in different environments: a molecular dynamics study

7 July 2018

1 reference

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Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A

7 July 2018

1 reference

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GROMACS: fast, flexible, and free

7 July 2018

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Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.

7 July 2018

1 reference

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NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

7 July 2018

1 reference

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The interaction of p53 with replication protein A mediates suppression of homologous recombination

7 July 2018

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

7 July 2018

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The Recombination-deficient Mutant RPA (rfa1-t11) Is Displaced Slowly from Single-stranded DNA by Rad51 Protein

7 July 2018

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The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding

7 July 2018

1 reference

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State of the art in studying protein folding and protein structure prediction using molecular dynamics methods.

7 July 2018

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Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae

7 July 2018

1 reference

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Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constants

7 July 2018

1 reference

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Anisotropy of fluctuation dynamics of proteins with an elastic network model

7 July 2018

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7 July 2018

Surfing the p53 network

1 reference

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Human replication protein A: global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Overcoming expression and purification problems of RhoGDI using a family of "parallel" expression vectors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Genetic analysis of yeast RPA1 reveals its multiple functions in DNA metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

p53, the cellular gatekeeper for growth and division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Replication protein A induces the unwinding of long double-stranded DNA regions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

The transactivator proteins VP16 and GAL4 bind replication factor A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Inhibition of DNA replication factor RPA by p53.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Recombinant replication protein A: expression, complex formation, and functional characterization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

Interactions of human replication protein A with oligonucleotides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3561959

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKS1291

Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKS1291

Promiscuity in protein-RNA interactions: conformational ensembles facilitate molecular recognition in the spliceosome: conformational diversity in U2AF⁶⁵ facilitates binding to diverse RNA sequences.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1093%2FNAR%2FGKS1291

Computer simulations of organic reactions in solution

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23267009

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23267009

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKS1291

1 reference

release_i7arjxacmbeqhb3rvjd2ndzl6y

2 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/i7arjxacmbeqhb3rvjd2ndzl6y

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

3561959

1 reference

2 August 2017

1 reference