Kinase drug discovery--what's next in the field? (Q34527876)

2 August 2017

title

Kinase drug discovery--what's next in the field? (English)

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2 August 2017

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ChEBI release 2020-05-28

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Dario R Alessi

2

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author name string

Philip Cohen

series ordinal

1

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2 August 2017

publication date

31 December 2012

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2 August 2017

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2 August 2017

volume

8

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2 August 2017

issue

1

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2 August 2017

page(s)

96-104

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Brain Penetrant LRRK2 Inhibitor

2 August 2017

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

7 July 2018

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A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation

7 July 2018

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7 July 2018

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

7 July 2018

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IRAK-4 inhibitors for inflammation

7 July 2018

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7 July 2018

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Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

7 July 2018

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7 July 2018

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ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

7 July 2018

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Targeting protein kinases for the development of anti-inflammatory drugs

7 July 2018

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7 July 2018

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7 July 2018

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From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 July 2018

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Emerging roles of pseudokinases

7 July 2018

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LKB1-dependent signaling pathways

7 July 2018

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The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

7 July 2018

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7 July 2018

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

7 July 2018

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

7 July 2018

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Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease

7 July 2018

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Human hypertension caused by mutations in WNK kinases

7 July 2018

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Paradoxical activation of Raf by a novel Raf inhibitor

7 July 2018

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

7 July 2018

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SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

7 July 2018

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

7 July 2018

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High-frequency variant p.T60M in NaCl cotransporter and blood pressure variability in Han Chinese

7 July 2018

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27 October 2018

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27 October 2018

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27 October 2018

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The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

27 October 2018

1 reference

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TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

27 October 2018

1 reference

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MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23276252

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23276252

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CB300610S

1 reference

2 August 2017

1 reference

2 August 2017

1 reference