The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins (Q34535813)

2 August 2017

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title

The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins (English)

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2 August 2017

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Henrik Birn

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2 August 2017

1 July 2006

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American Journal of Physiology - Renal Physiology

2 August 2017

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2 August 2017

291

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2 August 2017

F22-36

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2 August 2017

1

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Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1

2 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Potocytosis: Sequestration and Transport of Small Molecules by Caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Homocysteine and cardiovascular disease in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Diversity in rat tissue accumulation of vitamin B12 supports a distinct role for the kidney in vitamin B12 homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Maturational changes in endothelium-derived relaxations in newborn piglet pulmonary circulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Renal tubular reabsorption of folate mediated by folate binding protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Megalin binds and mediates cellular internalization of folate binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Holo-transcobalamin concentration and transcobalamin saturation reflect recent vitamin B12 absorption better than does serum vitamin B12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

In vitro and in vivo inactivation of transcobalamin II receptor by its antiserum

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Regulation of expression of transcobalamin II receptor in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Membrane expression and interactions of human transcobalamin II receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Role of rap in the biogenesis of lipoprotein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Update on cobalamin, folate, and homocysteine

21 January 2018

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https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Megalin and cubilin: multifunctional endocytic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Hydroxocobalamin reduces hyperhomocysteinemia in end-stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Significance of elevated cobalamin (vitamin B12) levels in blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

THE RENAL EXCRETION OF FOLIC ACID

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Specific activity of radiovitamin B12 in organs and subcellular liver fractions after injection of 58Co-labelled vitamin B12.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

A high-affinity folate binding protein in human urine. Radioligand binding characteristics, immunological properties and molecular size

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Canine Imerslund-Gräsbeck syndrome maps to a region orthologous to HSA14q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

21 January 2018

Folate-binding proteins

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Cellular signalling by lipoprotein receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Clathrin-dependent or not: is it still the question?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Ligand-induced conformation change in folate-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

A review of folate receptor alpha cycling and 5-methyltetrahydrofolate accumulation with an emphasis on cell models in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Influence on immunoreactive folate-binding proteins of extracellular folate concentration in cultured human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Measurement of endosome pH following folate receptor-mediated endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Megalin knockout mice as an animal model of low molecular weight proteinuria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Uptake of transcobalamin II-bound cobalamin by isolated rat kidney tubule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Folate binding in animal plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Membrane transport of folates

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Sequestration of GPI-anchored proteins in caveolae triggered by cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The Adaptor Protein ARH Escorts Megalin to and through Endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Vitamin B12 in the rat kidney. Evidence for an association with lysosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Regulated internalization of caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Functional coupling between a bafilomycin A1-sensitive proton pump and a probenecid-sensitive folate transporter in human placental choriocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Inherited disorders of cobalamin metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Synthesis and secretion of cobalamin binding proteins by opossum kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Endocytosis of GPI-linked membrane folate receptor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The crystal structures of two spermadhesins reveal the CUB domain fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Renal handling of albumin: a critical review of basic concepts and perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Folate receptor endocytosis and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Coat proteins and vesicle budding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

21 January 2018

Folate and vitamin B12

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Demonstration of high-affinity folate binding activity associated with the brush border membranes of rat kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Folate receptor type gamma is primarily a secretory protein due to lack of an efficient signal for glycosylphosphatidylinositol modification: protein characterization and cell type specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Identification of two putative novel folate receptor genes in humans and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Effects of dietary folate intake and folate binding protein-1 (Folbp1) on urinary speciation of sodium arsenate in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Physiology of folic acid in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Identification of an apical sorting determinant in the cytoplasmic tail of megalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Genetically heterogeneous selective intestinal malabsorption of vitamin B12: founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle East

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Lysosomal cobalamin accumulation in fibroblasts from a patient with an inborn error of cobalamin metabolism (cblF complementation group): visualization by electron microscope radioautography

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Localization of the murine reduced folate carrier as assessed by immunohistochemical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Defective forebrain development in mice lacking gp330/megalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Pathways for kidney-specific uptake of the steroid hormone 25-hydroxyvitamin D3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Transcobalamin II receptor interacts with megalin in the renal apical brush border membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Identification and characterization of two distinct ligand binding regions of cubilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00385.2005

10.1152/AJPRENAL.00385.2005

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

16760376