Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway (Q34538415)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

Increased hexosamine pathway flux and high fat feeding are not additive in inducing insulin resistance: evidence for a shared pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Robert C Cooksey

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

publication date

24 July 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

841-846

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

Insulin resistance is a cellular antioxidant defense mechanism

8 February 2020

cites work

1 reference

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Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance

7 July 2018

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Regulation of Akt signaling by O-GlcNAc in euglycemia.

7 July 2018

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Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity

7 July 2018

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

7 July 2018

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Inflammation and metabolic disorders

7 July 2018

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Reduction of O-GlcNAc protein modification does not prevent insulin resistance in 3T3-L1 adipocytes

7 July 2018

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The hexosamine signaling pathway: deciphering the "O-GlcNAc code"

7 July 2018

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O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress

7 July 2018

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O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar

7 July 2018

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Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia

7 July 2018

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Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta

7 July 2018

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Free fatty acids and pathogenesis of type 2 diabetes mellitus

7 July 2018

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Transgenic mice with increased hexosamine flux specifically targeted to beta-cells exhibit hyperinsulinemia and peripheral insulin resistance.

7 July 2018

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Perspective: Hexosamines and nutrient sensing

7 July 2018

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Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle

7 July 2018

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Mechanism of hexosamine-induced insulin resistance in transgenic mice overexpressing glutamine:fructose-6-phosphate amidotransferase: decreased glucose transporter GLUT4 translocation and reversal by treatment with thiazolidinedione.

7 July 2018

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat.

7 July 2018

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Glucose-fatty acid interactions in health and disease

7 July 2018

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Role of the glucosamine pathway in fat-induced insulin resistance

7 July 2018

1 reference

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Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

7 July 2018

1 reference

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Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030663

Hexosamines and insulin resistance

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030663

Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity

7 July 2018

1 reference

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In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats

7 July 2018

1 reference

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In vivo effects of glucosamine on insulin secretion and insulin sensitivity in the rat: possible relevance to the maladaptive responses to chronic hyperglycaemia

7 July 2018

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The subcellular distribution of terminal N-acetylglucosamine moieties. Localization of a novel protein-saccharide linkage, O-linked GlcNAc.

7 July 2018

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Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance

7 July 2018

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Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats

7 July 2018

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Activation of the hexosamine signaling pathway in adipose tissue results in decreased serum adiponectin and skeletal muscle insulin resistance.

21 January 2018

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Hexosamines stimulate leptin production in transgenic mice.

21 January 2018

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Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.

21 January 2018

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Pre-exposure to glucosamine induces insulin resistance of glucose transport and glycogen synthesis in isolated rat skeletal muscles. Study of mechanisms in muscle and in rat-1 fibroblasts overexpressing the human insulin receptor

21 January 2018

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Studies on L-glutamine D-fructose 6-phosphate amidotransferase. I. Feedback inhibition by uridine diphosphate-N-acetylglucosamine

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20658157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

O-linked N-acetylglucosamine is attached to proteins of the nuclear pore. Evidence for cytoplasmic and nucleoplasmic glycoproteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20658157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/20658157

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00726-010-0701-5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20658157%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

20658157

1 reference