Telomerase and telomeres: from basic biology to cancer treatment (Q34538689)

2 August 2017

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title

Telomerase and telomeres: from basic biology to cancer treatment (English)

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2 August 2017

Marco N Helder

1

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PubMed ID

11855380

2 August 2017

G Bea A Wisman

series ordinal

2

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PubMed ID

11855380

2 August 2017

G J van der Zee

series ordinal

3

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2 August 2017

1 January 2002

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2 August 2017

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2 August 2017

20

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2 August 2017

1

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2 August 2017

82-101

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The serial cultivation of human diploid cell strains

2 August 2017

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomeres shorten during ageing of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The emerging p53 gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomere dynamics and telomerase activity in in vitro immortalised human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Reversing time: origin of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Reconstitution of human telomerase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The RNA component of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase catalytic subunit homologs from fission yeast and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

A mammalian telomerase-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The telomerase reverse transcriptase: components and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Secondary structure of vertebrate telomerase RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of telomerase limits the growth of human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Functional requirement of p23 and Hsp90 in telomerase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Gene structure and expression of the mouse dyskeratosis congenita gene, dkc1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

A telomerase component is defective in the human disease dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Complex transcriptional regulatory mechanisms control expression of the E2F3 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

TRF1 binds a bipartite telomeric site with extreme spatial flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Crystal structure of the two-RRM domain of hnRNP A1 (UP1) complexed with single-stranded telomeric DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

A human telomeric protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomeric localization of TRF2, a novel human telobox protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

TRF1 is a dimer and bends telomeric DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Control of telomere length by the human telomeric protein TRF1

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

TRF2 Protects Human Telomeres from End-to-End Fusions

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

TIN2, a new regulator of telomere length in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Mammalian telomeres end in a large duplex loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Processing of telomeric DNA ends requires the passage of a replication fork

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Nucleoside transport and its significance for anticancer drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Intracellular phosphorylation of zidovudine (ZDV) and other nucleoside reverse transcriptase inhibitors (RTI) used for human immunodeficiency virus (HIV) infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Mechanisms of clinical resistance by HIV-I variants to zidovudine and the paradox of reverse transcriptase sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Cloning and characterization of human and mouse telomerase RNA gene promoter sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activity in human leukemic cell lines is inhibited by antisense pentadecadeoxynucleotides targeted against c-myc mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

21 January 2018

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Identification of Mad as a repressor of the human telomerase (hTERT) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of telomerase increases the susceptibility of human malignant glioblastoma cells to cisplatin-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of human telomerase by a retrovirus expressing telomeric antisense RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of human telomerase by 2'-O-methyl-RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of human telomerase activity by peptide nucleic acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Cellular delivery of peptide nucleic acids and inhibition of human telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Specific inhibition of human telomerase activity by transfection reagent, FuGENE6-antisense phosphorothioate oligonucleotide complex in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase protein rather than its RNA is the target of phosphorothioate-modified oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Treatment of prostate cancer in vitro and in vivo with 2-5A-anti-telomerase RNA component.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The catalytic subunit of telomerase protects neurons against amyloid beta-peptide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The catalytic subunit of telomerase is expressed in developing brain neurons and serves a cell survival-promoting function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase is controlled by protein kinase Calpha in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Cytotoxic T cell immunity against telomerase reverse transcriptase in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Induction of cytotoxic T cell responses and tumor immunity against unrelated tumors using telomerase reverse transcriptase RNA transfected dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activity in normal and malignant hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Agents that target telomerase and telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

TRF1 promotes parallel pairing of telomeric tracts in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Tankyrase promotes telomere elongation in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

T Cell Telomere Length in HIV-1 Infection: No Evidence for Increased CD4+ T Cell Turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase targeting in cancer treatment: new developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Preferential incorporation of 3'-azido-2',3'-dideoxythymidine into telomeric DNA and Z-DNA-containing regions of Chinese hamster ovary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Transport and mode of action of nucleoside derivatives used in chemical and antiviral therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Antisense of oligonucleotides and the inhibition of oncogene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Effect of antisense human telomerase RNA transfection on the growth of human gastric cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Hammerhead ribozyme-mediated inhibition of telomerase activity in extracts of human hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Inhibition of unwinding of G-quadruplex structures by Sgs1 helicase in the presence of N,N'-bis[2-(1-piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic diimide, a G-quadruplex-interactive ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Is telomerase a universal cancer target?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activity concentrates in the mitotically active segments of human hair follicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase activity of normal tissues and neoplasms in rat colon carcinogenesis induced by methylazoxymethanol acetate and its difference from that of human colonic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Telomerase: immortality enzyme or oncogene?

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

Clinical evaluation of biologically targeted drugs: obstacles and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FCNV-120000370

21 January 2018

Identifiers

DOI

10.1081/CNV-120000370

1 reference

2 August 2017

1 reference

PubMed ID

11855380