Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. (Q34554699)

3 August 2017

Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4. (English)

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3 August 2017

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Tasuku Honjo

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3 August 2017

Hans Christian Probst

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Hans Christian Probst

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author name string

Kathy McCoy

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3 August 2017

Taku Okazaki

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3 August 2017

Maries van den Broek

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3 August 2017

language of work or name

English

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publication date

30 January 2005

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3 August 2017

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3 August 2017

6

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3 August 2017

280-286

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3 August 2017

3

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The anatomy of T-cell activation and tolerance

3 August 2017

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Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.

21 January 2018

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Promiscuous gene expression and central T-cell tolerance: more than meets the eye.

21 January 2018

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Gene defect behind APECED: a new clue to autoimmunity

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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The enemy within: keeping self-reactive T cells at bay in the periphery

21 January 2018

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Dendritic Cell Function in Vivo during the Steady State: A Role in Peripheral Tolerance

21 January 2018

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Tolerogenic dendritic cells

21 January 2018

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Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses

21 January 2018

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

21 January 2018

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

21 January 2018

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

21 January 2018

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

21 January 2018

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

21 January 2018

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

21 January 2018

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New regulatory co-receptors: inducible co-stimulator and PD-1.

21 January 2018

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Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

21 January 2018

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Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance.

21 January 2018

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Dendritic cells in immunity and tolerance-do they display opposite functions?

21 January 2018

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Antigen presentation and T cell stimulation by dendritic cells

21 January 2018

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Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node

21 January 2018

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The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens

21 January 2018

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Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection.

21 January 2018

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Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression

21 January 2018

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A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells.

21 January 2018

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In vivo detection of dendritic cell antigen presentation to CD4(+) T cells.

21 January 2018

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

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Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans

21 January 2018

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Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells

21 January 2018

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Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance

21 January 2018

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Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo

21 January 2018

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Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells.

21 January 2018

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Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

21 January 2018

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Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen.

21 January 2018

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Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells

21 January 2018

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Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells

21 January 2018

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Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8(+) T cells independently of CD4(+) T cell help.

21 January 2018

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Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice

21 January 2018

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Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

21 January 2018

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CTLA-4 can function as a negative regulator of T cell activation

21 January 2018

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Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

21 January 2018

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Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

21 January 2018

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Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells

21 January 2018

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Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

21 January 2018

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7 January 2021

Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

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7 January 2021

Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells

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7 January 2021

Cutting edge: competition for APC by CTLs of different specificities is not functionally important during induction of antiviral responses

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7 January 2021

Identifiers

DOI

10.1038/NI1165

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3 August 2017

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