Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity (Q35762422)

10 August 2017

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title

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity (English)

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10 August 2017

Lieping Chen

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10 August 2017

1 May 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

5

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10 August 2017

336-347

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10 August 2017

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Immunological ignorance of silent antigens as an explanation of tumor evasion

31 March 2020

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Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

31 March 2020

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Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

31 March 2020

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Activation rules: the two-signal theories of immune activation

31 March 2020

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Does the immune system see tumors as foreign or self?

31 March 2020

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

31 March 2020

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

31 March 2020

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

31 March 2020

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CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

31 March 2020

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Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

31 March 2020

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B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via T-T interactions [corrections].

31 March 2020

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

31 March 2020

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CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism

31 March 2020

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In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance.

31 March 2020

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Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells

31 March 2020

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Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta

31 March 2020

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

31 March 2020

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Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation

31 March 2020

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Structural mechanisms of costimulation

31 March 2020

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Molecular basis of T cell inactivation by CTLA-4

31 March 2020

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Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

31 March 2020

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

31 March 2020

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

31 March 2020

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CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

31 March 2020

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Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells

31 March 2020

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Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig

31 March 2020

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CTLA-4-Ig regulates tryptophan catabolism in vivo.

31 March 2020

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Modulation of tryptophan catabolism by regulatory T cells.

31 March 2020

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Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

31 March 2020

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T cell apoptosis by tryptophan catabolism

31 March 2020

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Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

31 March 2020

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

31 March 2020

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

31 March 2020

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

31 March 2020

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Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

31 March 2020

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The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice

31 March 2020

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Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

31 March 2020

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Preferential contribution of B7‐H1 to programmed death‐1‐mediated regulation of hapten‐specific allergic inflammatory responses

31 March 2020

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Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism.

31 March 2020

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PD-1 inhibits antiviral immunity at the effector phase in the liver

31 March 2020

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Structure and chromosomal localization of the human PD-1 gene (PDCD1)

31 March 2020

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The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors

31 March 2020

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PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

31 March 2020

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

31 March 2020

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Absence of Programmed Death Receptor 1 Alters Thymic Development and Enhances Generation of CD4/CD8 Double-Negative TCR-Transgenic T Cells

31 March 2020

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

31 March 2020

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

31 March 2020

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Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

31 March 2020

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B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

31 March 2020

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Expression of programmed death 1 ligands by murine T cells and APC

31 March 2020

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B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis

31 March 2020

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B7 family molecules: novel immunomodulators at the maternal-fetal interface

31 March 2020

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B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression

31 March 2020

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B7 family molecules are favorably positioned at the human maternal-fetal interface

31 March 2020

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B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy.

31 March 2020

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Keratinocytes Induce Local Tolerance to Skin Graft by Activating Interleukin-10–Secreting T Cells in the Context of Costimulation Molecule B7-H11

31 March 2020

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Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.

31 March 2020

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Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production

31 March 2020

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B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells

31 March 2020

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Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor

31 March 2020

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PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

31 March 2020

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Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation

31 March 2020

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Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection

31 March 2020

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B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.

31 March 2020

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Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

31 March 2020

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Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis

31 March 2020

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Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.

31 March 2020

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Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells

31 March 2020

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Hepatic T cells and liver tolerance

31 March 2020

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B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.

31 March 2020

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B7-H4, a molecule of the B7 family, negatively regulates T cell immunity

31 March 2020

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B7S1, a novel B7 family member that negatively regulates T cell activation

31 March 2020

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B7x: a widely expressed B7 family member that inhibits T cell activation

31 March 2020

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Genomic Organization and Expression Analysis of B7-H4, an Immune Inhibitory Molecule of the B7 Family

31 March 2020

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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

31 March 2020

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B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production

31 March 2020

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Characterization of mouse and human B7-H3 genes

31 March 2020

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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

31 March 2020

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Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss

31 March 2020

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Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains.

31 March 2020

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Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

31 March 2020

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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

31 March 2020

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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

31 March 2020

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B7-H1 pathway and its role in the evasion of tumor immunity.

31 March 2020

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Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity

31 March 2020

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Programmed death-1 targeting can promote allograft survival

31 March 2020

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Stimulating PD-1???negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival1

31 March 2020

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Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.

31 March 2020

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Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1349

1 reference

10 August 2017

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PubMed ID

15122199