Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein (Q34555685)

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English	Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein	scientific article

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scholarly article

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Europe PubMed Central

3 August 2017

Differential processing of let-7a precursors influences RRM2 expression and chemosensitivity in pancreatic cancer: role of LIN-28 and SET oncoprotein (English)

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Europe PubMed Central

3 August 2017

pancreatic cancer

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based on heuristic

inferred from title

author name string

Yangzom Doma Bhutia

1

1 reference

Europe PubMed Central

3 August 2017

Sau Wai Hung

2

1 reference

Europe PubMed Central

3 August 2017

Madeline Krentz

3

1 reference

Europe PubMed Central

3 August 2017

Dimal Patel

4

1 reference

Europe PubMed Central

3 August 2017

Dylan Lovin

5

1 reference

Europe PubMed Central

3 August 2017

Radhika Manoharan

6

1 reference

Europe PubMed Central

3 August 2017

J Michael Thomson

7

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Europe PubMed Central

3 August 2017

Rajgopal Govindarajan

8

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Europe PubMed Central

3 August 2017

language of work or name

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publication date

15 January 2013

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Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

8

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Europe PubMed Central

3 August 2017

1

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Europe PubMed Central

3 August 2017

e53436

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Europe PubMed Central

3 August 2017

copyright license

Creative Commons Attribution 4.0 International

15 January 2013

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April 2022 Public Data File from Crossref

copyright status

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Overcoming nucleoside analog chemoresistance of pancreatic cancer: a therapeutic challenge

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7 July 2018

Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer.

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7 July 2018

MicroRNAs in development and disease

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7 July 2018

Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1

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Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice.

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Functional analysis of microRNAs in human hepatocellular cancer stem cells

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CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells

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7 July 2018

Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

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7 July 2018

LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans

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Pancreatic cancer: understanding and overcoming chemoresistance

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Targeting microRNAs in cancer: rationale, strategies and challenges

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The potential functions of primary microRNAs in target recognition and repression

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7 July 2018

The translational regulator eIF3a: the tricky eIF3 subunit!

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7 July 2018

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

MicroRNA let-7: an emerging next-generation cancer therapeutic

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7 July 2018

Recent developments in palliative chemotherapy for locally advanced and metastatic pancreas cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras

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7 July 2018

Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

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7 July 2018

Clinical pharmacology and pharmacogenetics of gemcitabine

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7 July 2018

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

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7 July 2018

let-7 MicroRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

Expression of multidrug resistance-associated protein 2 is involved in chemotherapy resistance in human pancreatic cancer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

The let-7 family of microRNAs

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7 July 2018

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.

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7 July 2018

Switching from repression to activation: microRNAs can up-regulate translation

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7 July 2018

The let-7 microRNA represses cell proliferation pathways in human cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.

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7 July 2018

Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

Extensive post-transcriptional regulation of microRNAs and its implications for cancer

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7 July 2018

Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3546076

7 July 2018

MicroRNA expression profiles classify human cancers

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7 July 2018

RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance

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7 July 2018

Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone.

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7 July 2018

S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region

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7 July 2018

RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine

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7 July 2018

The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53

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Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity

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7 July 2018

Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis

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7 July 2018

Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

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7 July 2018

Controlled protein degradation regulates ribonucleotide reductase activity in proliferating mammalian cells during the normal cell cycle and in response to DNA damage and replication blocks

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7 July 2018

Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line

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Ribonucleotide reductase subunit M2 mRNA expression in pretreatment biopsies obtained from unresectable pancreatic carcinomas

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27 October 2018

Analysis of ribonucleotide reductase M2 mRNA levels in patient samples after GTI-2040 antisense drug treatment

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Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis

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27 October 2018

Human ribonucleotide reductase M2 subunit gene amplification and transcriptional regulation in a homogeneous staining chromosome region responsible for the mechanism of drug resistance

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c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene

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Lin28: A microRNA regulator with a macro role

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Hypermethylation of let-7a-3 in epithelial ovarian cancer is associated with low insulin-like growth factor-II expression and favorable prognosis

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https://pubmed.ncbi.nlm.nih.gov/23335963

12 December 2020

based on heuristic

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10.1371/JOURNAL.PONE.0053436

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Europe PubMed Central

3 August 2017

2013PLoSO...853436B

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1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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