Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response (Q24650185)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416980%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response (English)

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27 January 2020

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1

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27 January 2020

Natasha J. Caplen

4

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27 January 2020

author name string

Tamara L Jones

2

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27 January 2020

Scott E Martin

3

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27 January 2020

Yves Pommier

5

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27 January 2020

language of work or name

English

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publication date

5 May 2009

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Journal of Biological Chemistry

27 January 2020

published in

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27 January 2020

volume

284

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27 January 2020

issue

27

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27 January 2020

page(s)

18085-18095

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Chk2 activates E2F-1 in response to DNA damage

27 January 2020

cites work

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7 April 2017

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Checkpoint deficient rad53-11 yeast cannot accumulate dNTPs in response to DNA damage

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage

7 April 2017

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Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo

7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

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7 April 2017

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Essential role of Chk1 in S phase progression through regulation of RNR2 expression

28 September 2017

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Phase I study of GTI-2040, an antisense to ribonucleotide reductase, in combination with high-dose cytarabine in patients with acute myeloid leukemia

28 September 2017

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Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F-binding site and an upstream promoter activating region

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis

28 September 2017

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S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function

28 September 2017

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28 September 2017

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Correlations between S and G2 arrest and the cytotoxicity of camptothecin in human colon carcinoma cells.

28 September 2017

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28 September 2017

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Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

28 September 2017

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Immunocytochemical evidence for the cytoplasmic localization and differential expression during the cell cycle of the M1 and M2 subunits of mammalian ribonucleotide reductase

28 September 2017

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28 September 2017

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28 September 2017

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast

28 September 2017

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Localization of ribonucleotide reductase in mammalian cells

30 May 2018

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Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

30 May 2018

1 reference

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EPR stopped-flow studies of the reaction of the tyrosyl radical of protein R2 from ribonucleotide reductase with hydroxyurea

30 May 2018

1 reference

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

30 May 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.003020

A phase I study of capecitabine and a modulatory dose of irinotecan in metastatic breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.003020

p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.003020

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

1 reference

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Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic cata

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.003020

Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress.

21 January 2018

1 reference

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Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

21 January 2018

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12 December 2020

Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system

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12 December 2020

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function

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12 December 2020

Apoptotic response to camptothecin and 7-hydroxystaurosporine (UCN-01) in the 8 human breast cancer cell lines of the NCI Anticancer Drug Screen: multifactorial relationships with topoisomerase I, protein kinase C, Bcl-2, p53, MDM-2 and caspase path

1 reference

12 December 2020

A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors

1 reference

12 December 2020

A Phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma

1 reference

12 December 2020

UCN-01 (7-hydroxystauorsporine) blocks PMA-induced maturation and reciprocally promotes apoptosis in human myelomonocytic leukemia cells (U937).

1 reference

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1074/JBC.M109.003020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416980%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19416980%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

19416980

1 reference