Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas. (Q34555820)

PubMed publication ID

16899734

3 August 2017

title

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas (English)

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11 May 2020

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2

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Giuseppe Battaglia

3

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Enrico De Smaele

8

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11 May 2020

Anna Saran

9

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Felice Giangaspero

12

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Ferdinando Nicoletti

13

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11 May 2020

author name string

Luisa Iacovelli

1

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Simonetta Pazzaglia

4

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Paola Spinsanti

6

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Alessandra Caruso

7

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Alberto Gulino

10

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Eleonora Aronica

5

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Mara D'Onofrio

11

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11 May 2020

language of work or name

English

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publication date

1 August 2006

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PubMed publication ID

16899734

3 August 2017

published in

Journal of Neuroscience

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volume

26

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issue

32

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page(s)

8388-8397

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APC mutations in sporadic medulloblastomas

11 May 2020

cites work

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12 December 2020

Nuclear localization and mutation of beta-catenin in medulloblastomas

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Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

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Treatment controversies in medulloblastoma

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Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas.

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Presynaptic modulation by group III metabotropic glutamate receptors (mGluRs) of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells

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Clinical and molecular stratification of disease risk in medulloblastoma

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Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells

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The WHO classification of tumors of the nervous system

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Gli and hedgehog in cancer: tumours, embryos and stem cells.

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Mutations in SUFU predispose to medulloblastoma

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Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase/phosphatidylinositol-3-kinase pathways

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Medulloblastoma growth inhibition by hedgehog pathway blockade

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Role of Wnt pathway in medulloblastoma oncogenesis.

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High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice

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ERBB2 up-regulates S100A4 and several other prometastatic genes in medulloblastoma.

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AXIN1 mutations but not deletions in cerebellar medulloblastomas

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What's new in neuro-oncology? Recent advances in medulloblastoma

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Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia

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12 December 2020

(-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection.

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12 December 2020

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

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12 December 2020

Medulloblastoma: signalling a change in treatment

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12 December 2020

Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2)

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12 December 2020

Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

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12 December 2020

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

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12 December 2020

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

1 reference

12 December 2020

PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors.

1 reference

12 December 2020

Expression patterns of Group III metabotropic glutamate receptors mGluR4 and mGluR8 in multiple sclerosis lesions

1 reference

12 December 2020

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.

1 reference

12 December 2020

Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice.

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12 December 2020

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1 reference

12 December 2020

Temporal and depolarization-induced changes in the absolute amounts of mRNAs encoding metabotropic glutamate receptors in cerebellar granule neurons in vitro

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12 December 2020

Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy.

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12 December 2020

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

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12 December 2020

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4.

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

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12 December 2020

Molecular characterization and localization of human metabotropic glutamate receptor type 4

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Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins

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12 December 2020

Sporadic medulloblastomas contain PTCH mutations.

1 reference

12 December 2020

Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched.

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12 December 2020

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1 reference

12 December 2020

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

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12 December 2020

Prognostic significance of HER2 and HER4 coexpression in childhood medulloblastoma.

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12 December 2020

WNT-7a induces axonal remodeling and increases synapsin I levels in cerebellar neurons

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12 December 2020

Sporadic medulloblastomas contain oncogenic beta-catenin mutations.

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12 December 2020

Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system

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12 December 2020

Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis

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12 December 2020

10.1523/JNEUROSCI.2285-06.2006

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673797&resulttype=core&format=json

11 May 2020

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11 May 2020

PubMed publication ID

16899734

1 reference