Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters (Q34559944)

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English	Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

Strong induction of PCSK9 gene expression through HNF1alpha and SREBP2: mechanism for the resistance to LDL-cholesterol lowering effect of statins in dyslipidemic hamsters (English)

1 reference

Europe PubMed Central

3 August 2017

Sahng Wook Park

object named as

Sahng Wook Park

7

0 references

Fredric B Kraemer

object named as

Fredric B Kraemer

4

0 references

object named as

Nabil G Seidah

6

0 references

author name string

Bin Dong

1

1 reference

Europe PubMed Central

3 August 2017

Minhao Wu

2

1 reference

Europe PubMed Central

3 August 2017

Hai Li

3

1 reference

Europe PubMed Central

3 August 2017

Khosrow Adeli

5

1 reference

Europe PubMed Central

3 August 2017

Jingwen Liu

8

1 reference

Europe PubMed Central

3 August 2017

publication date

4 January 2010

1 reference

Europe PubMed Central

3 August 2017

Journal of Lipid Research

1 reference

Europe PubMed Central

3 August 2017

51

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Europe PubMed Central

3 August 2017

1486-1495

1 reference

Europe PubMed Central

3 August 2017

6

1 reference

Europe PubMed Central

3 August 2017

Hepatocyte nuclear factor 1alpha plays a critical role in PCSK9 gene transcription and regulation by the natural hypocholesterolemic compound berberine

1 reference

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7 July 2018

Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels

1 reference

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7 July 2018

Hepatic insulin resistance, metabolic syndrome and cardiovascular disease

1 reference

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Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells

1 reference

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7 July 2018

Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys

1 reference

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7 July 2018

Identification of mRNA binding proteins that regulate the stability of LDL receptor mRNA through AU-rich elements

1 reference

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7 July 2018

Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease

1 reference

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7 July 2018

Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

1 reference

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7 July 2018

Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment.

1 reference

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7 July 2018

Berberine decreases PCSK9 expression in HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035512

7 July 2018

Plasma PCSK9 preferentially reduces liver LDL receptors in mice

1 reference

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7 July 2018

Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.

1 reference

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7 July 2018

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation

1 reference

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7 July 2018

Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis

1 reference

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7 July 2018

Molecular biology of PCSK9: its role in LDL metabolism

1 reference

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7 July 2018

The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035512

7 July 2018

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3035512

7 July 2018

Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine

1 reference

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Atorvastatin reverses age-related reduction in rat hepatic PPARalpha and HNF-4

1 reference

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7 July 2018

Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

1 reference

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7 July 2018

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia

1 reference

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The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation

1 reference

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7 July 2018

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism

1 reference

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7 July 2018

Subchronic toxicity of atorvastatin, a hydroxymethylglutaryl-coenzyme A reductase inhibitor, in beagle dogs.

1 reference

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7 July 2018

The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins

1 reference

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21 January 2018

Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M003566

21 January 2018

High doses of atorvastatin and simvastatin induce key enzymes involved in VLDL production

1 reference

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21 January 2018

Effect of rosuvastatin on hepatic production of apolipoprotein B-containing lipoproteins in an animal model of insulin resistance and metabolic dyslipidemia

1 reference

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Effect of rosuvastatin on insulin sensitivity in an animal model of insulin resistance: evidence for statin-induced hepatic insulin sensitization

1 reference

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PCSK9 function and physiology.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M003566

21 January 2018

PCSK9 as a therapeutic target of dyslipidemia

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M003566

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Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9.

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M003566

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Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo

1 reference

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A new on-line dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC.

1 reference

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27 October 2018

Identifiers

10.1194/JLR.M003566

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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