Structure of an Hsp90-Cdc37-Cdk4 complex. (Q34562863)

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29 December 2019

title

Structure of an Hsp90-Cdc37-Cdk4 complex (English)

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29 December 2019

9

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Frank Sobott

3

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29 December 2019

Maruf M U Ali

5

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Chrisostomos Prodromou

6

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29 December 2019

Carol V. Robinson

7

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8

Helen R Saibil

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29 December 2019

author name string

Cara K Vaughan

1

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29 December 2019

Ulrich Gohlke

2

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Valerie M Good

4

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29 December 2019

publication date

1 September 2006

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29 December 2019

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29 December 2019

volume

23

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issue

5

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29 December 2019

page(s)

697-707

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Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

29 December 2019

cites work

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Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37.

7 July 2018

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Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding

7 July 2018

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Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

7 July 2018

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Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex.

7 July 2018

1 reference

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Investigation of intact protein complexes by mass spectrometry.

7 July 2018

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CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

7 July 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

7 July 2018

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Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone

7 July 2018

1 reference

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Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery

7 July 2018

1 reference

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The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

7 July 2018

1 reference

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Identification of a conserved sequence motif that promotes Cdc37 and cyclin D1 binding to Cdk4.

7 July 2018

1 reference

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Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

7 July 2018

1 reference

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Accurate determination of local defocus and specimen tilt in electron microscopy

7 July 2018

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Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

7 July 2018

1 reference

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Protein complexes gain momentum.

7 July 2018

1 reference

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The Cdc37 protein kinase-binding domain is sufficient for protein kinase activity and cell viability

7 July 2018

1 reference

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Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.

7 July 2018

1 reference

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TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

7 July 2018

1 reference

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Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1.

7 July 2018

1 reference

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Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

7 July 2018

1 reference

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Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

7 July 2018

1 reference

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Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase

7 July 2018

1 reference

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Modulation of Akt kinase activity by binding to Hsp90

7 July 2018

1 reference

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The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

7 July 2018

1 reference

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The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues

7 July 2018

1 reference

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Hsp90 is essential for the synthesis and subsequent membrane association, but not the maintenance, of the Src-kinase p56(lck).

7 July 2018

1 reference

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Molecular chaperones: containers and surfaces for folding, stabilising or unfolding proteins

7 July 2018

1 reference

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Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

7 July 2018

1 reference

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Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription

7 July 2018

1 reference

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Situs: A package for docking crystal structures into low-resolution maps from electron microscopy

7 July 2018

1 reference

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p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

7 July 2018

1 reference

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Steroid receptor interactions with heat shock protein and immunophilin chaperones

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Interaction between Cdc37 and Cdk4 in human cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

7 July 2018

1 reference

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A new generation of the IMAGIC image processing system

7 July 2018

1 reference

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Physical interaction of mammalian CDC37 with CDK4

7 July 2018

1 reference

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Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

7 July 2018

1 reference

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Active and inactive protein kinases: structural basis for regulation

7 July 2018

1 reference

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Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase

7 July 2018

1 reference

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Heat-shock protein hsp90 governs the activity of pp60v-src kinase

7 July 2018

1 reference

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Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association

7 July 2018

1 reference

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A client-binding site of Cdc37.

7 July 2018

1 reference

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Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle

27 October 2018

1 reference

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Definition of protein kinase sequence motifs that trigger high affinity binding of Hsp90 and Cdc37.

27 October 2018

1 reference

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Biochemical and structural studies of the interaction of Cdc37 with Hsp90.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Functional Dissection of Cdc37: Characterization of Domain Structure and Amino Acid Residues Critical for Protein Kinase Binding

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

High Affinity Binding of Hsp90 Is Triggered by Multiple Discrete Segments of Its Kinase Clients

27 October 2018

1 reference

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A tandem mass spectrometer for improved transmission and analysis of large macromolecular assemblies.

27 October 2018

1 reference

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Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells

27 October 2018

1 reference

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Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5704897

Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia

27 October 2018

1 reference

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10.1016/J.MOLCEL.2006.07.016

9 December 2018

Identifiers

DOI

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29 December 2019

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29 December 2019

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