Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein. (Q34567234)

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English	Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein.	scientific article

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23 February 2020

Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein (English)

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23 February 2020

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23 February 2020

Marie K Mankowski

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Marie K Mankowski

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23 February 2020

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Roger G Ptak

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23 February 2020

Julio Martín-García

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Julio Martín-García

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23 February 2020

author name string

Isaac Zentner

1

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23 February 2020

Luz-Jeannette Sierra

2

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23 February 2020

Ayesha K Fraser

3

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23 February 2020

Lina Maciunas

4

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23 February 2020

Andrei Vinnik

6

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23 February 2020

Simon Cocklin

10

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23 February 2020

publication date

29 January 2013

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23 February 2020

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23 February 2020

8

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23 February 2020

3

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23 February 2020

426-432

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23 February 2020

Genetic evidence for an interaction between human immunodeficiency virus type 1 matrix and alpha-helix 2 of the gp41 cytoplasmic tail

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

TIP47 is required for the production of infectious HIV-1 particles from primary macrophages.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Myristoylation-dependent replication and assembly of human immunodeficiency virus 1

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

A myristoyl switch regulates membrane binding of HIV-1 Gag.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Point Mutations in the HIV-1 Matrix Protein Turn Off the Myristyl Switch

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Entropic switch regulates myristate exposure in the HIV-1 matrix protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Localization of human immunodeficiency virus type 1 Gag and Env at the plasma membrane by confocal imaging

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Interactions of HIV-1 Gag with assembly cofactors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Gag localization and virus-like particle release mediated by the matrix domain of human T-lymphotropic virus type 1 Gag are less dependent on phosphatidylinositol-(4,5)-bisphosphate than those mediated by the matrix domain of HIV-1 Gag

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Assembly and replication of HIV-1 in T cells with low levels of phosphatidylinositol-(4,5)-bisphosphate.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Highly drug-resistant HIV-1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Ligation independent cloning vectors for expression of SUMO fusions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Protein production by auto-induction in high density shaking cultures

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201200577

21 January 2018

Opposing effects of human immunodeficiency virus type 1 matrix mutations support a myristyl switch model of gag membrane targeting.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of human immunodeficiency virus type 1 Gag to membrane: role of the matrix amino terminus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exploring "one-shot" kinetics and small molecule analysis using the ProteOn XPR36 array biosensor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription Factor DLX5 As a New Target for Promising Antitumor Agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct interaction between the envelope and matrix proteins of HIV-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential membrane binding of the human immunodeficiency virus type 1 matrix protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human immunodeficiency virus type 1 protease triggers a myristoyl switch that modulates membrane binding of Pr55(gag) and p17MA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23361947

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/CMDC.201200577

1 reference

https://api.fatcat.wiki/v0/release/hatde35ur5eqjjzogjgobhaazi

30 July 2022

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30 July 2022

based on heuristic

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23361947%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://api.fatcat.wiki/v0/release/hatde35ur5eqjjzogjgobhaazi

30 July 2022

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