Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. (Q34568892)

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14 February 2020

title

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease (English)

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15

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Elizabeth Hexner

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author name string

Yi Zhang

1

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Ashley R Sandy

2

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Jina Wang

3

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Vedran Radojcic

4

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Gloria T Shan

5

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Ivy T Tran

6

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Ann Friedman

7

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Koji Kato

8

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Shan He

9

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Shuaiying Cui

10

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Dale M Frank

12

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Stephen G Emerson

13

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Warren S Pear

14

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language of work or name

English

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publication date

24 September 2010

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14 February 2020

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volume

117

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issue

1

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page(s)

299-308

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Therapeutic antibody targeting of individual Notch receptors

14 February 2020

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Notch signaling in the hematopoietic system

7 July 2018

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Acute graft-versus-host disease: from the bench to the bedside

7 July 2018

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Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease

7 July 2018

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The canonical Notch signaling pathway: unfolding the activation mechanism

7 July 2018

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Notch regulates cytolytic effector function in CD8+ T cells.

7 July 2018

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Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

7 July 2018

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The different faces of Notch in T-helper-cell differentiation

7 July 2018

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

7 July 2018

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Interleukin-23 secretion by donor antigen-presenting cells is critical for organ-specific pathology in graft-versus-host disease

7 July 2018

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IL-17 contributes to CD4-mediated graft-versus-host disease

7 July 2018

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In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity

7 July 2018

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Notch1 signaling and regulatory T cell function

7 July 2018

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Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells

7 July 2018

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Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantation

7 July 2018

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

7 July 2018

1 reference

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Notch signalling during peripheral T-cell activation and differentiation

7 July 2018

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Immunobiology of allogeneic hematopoietic stem cell transplantation

7 July 2018

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The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

7 July 2018

1 reference

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Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation

7 July 2018

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Induction of tumor immunity following allogeneic stem cell transplantation

7 July 2018

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Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta

7 July 2018

1 reference

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Notch signaling is an important regulator of type 2 immunity.

7 July 2018

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New CFSE-based assay to determine susceptibility to lysis by cytotoxic T cells of leukemic precursor cells within a heterogeneous target cell population

7 July 2018

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Preterminal host dendritic cells in irradiated mice prime CD8+ T cell-mediated acute graft-versus-host disease

7 July 2018

1 reference

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Cytolytic pathways in haematopoietic stem-cell transplantation

7 July 2018

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IL-15 and IL-2: a matter of life and death for T cells in vivo

7 July 2018

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Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.

7 July 2018

1 reference

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Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice

7 July 2018

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Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation

7 July 2018

1 reference

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A coded histologic study of hepatic graft-versus-host disease after human bone marrow transplantation

7 July 2018

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

7 July 2018

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Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.

27 October 2018

1 reference

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Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

27 October 2018

1 reference

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

27 October 2018

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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

27 October 2018

1 reference

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

27 October 2018

1 reference

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Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.

27 October 2018

1 reference

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Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037751

Notch signaling augments T cell responsiveness by enhancing CD25 expression

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3037751

Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells

27 October 2018

1 reference

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Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells

27 October 2018

1 reference

12 December 2020

Graft-versus-host disease

1 reference

12 December 2020

Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation

1 reference

12 December 2020

Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question

1 reference

12 December 2020

Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect

1 reference

12 December 2020

Temporal discordance between graft-versus-leukemia and graft-versus-host responses: a strategy for the separation of graft-versus-leukemia/graft-versus-host reactivity?

1 reference

12 December 2020

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin

1 reference

12 December 2020

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

1 reference

12 December 2020

Notch signaling in the immune system

1 reference

12 December 2020

10.1182/BLOOD-2010-03-271940

Identifiers

DOI

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14 February 2020

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14 February 2020

PubMed publication ID

20870902

1 reference